St. Louis is an outstanding destination for a fun and memorable vacation. The fascinating city in Missouri boasts an amazing arts-and-culture scenario, parks, waterways, extensive trails, and attractions. You can take a tram ride to the top of the 630-foot (192-meter) Gateway Arch. Moreover, visit Saint Louis Zoo, which houses over 16,000 species. You will love to spot lions, tigers, bears, monkeys, and more wildlife here. Reconnect with nature at the beautiful Forest Park, which features lakes, nature reserves, streams, and forests. If you’re spending your holiday with a special someone, don’t miss out on the various seafood restaurants in St. Louis. After an exciting day, relaxing in a cozy boutique hotel will charge you up for another fun-filled day. So, book one of these best boutique hotels in St Louis, Missouri, for a pleasant stay.
We handpicked these listings carefully, considering (wherever possible) Superhost status, recent guest reviews, location, accommodation type, prices, availability of dates, decor, and amenities. The image galleries get refreshed with the latest updates regularly. They were last updated on April 14, 2024.
1. The Cheshire (from USD 153)
While coolness is subjective, The Cheshire’s stunningly handsome medieval decor and aesthetics make it stand out, and thus, cool. This hotel in St. Louis offers quality comfort and service. Guests will sleep in beds dressed in hypoallergenic Egyptian cotton sheets. Come morning, they are treated to a delicious English breakfast to start their day with. There are plenty of ways for patrons to spend their day, such as by taking a dip in the pool or relaxing with drinks from the poolside bar.
If you are looking to enjoy a slow-paced nightlife, there are several piano bars nearby. Places such as The Hideaway have a very casual setting, while the Chase Club invites those looking for a super-chic ambiance.
The Cheshire
Address: 6300 Clayton Rd
4.65 km (2.9 mi) from Cathedral Basilica of Saint Louis
Top guest reviews
Cleanliness:
spacious rooms good dinner in the bar very quiet and comfortableHost:
the friendliest staff i’ve ever encounteredthe staff was very friendly and flexibleclean property the staff were wonderful and kindsuper friendly staff cute decor great pub and good breakfast - overall a good experienceRead more reviewsLocation:
we’ve stayed here a few times the location is central to many of the city’s best restaurants and sitesEarn OneKeyCash for every dollar spent on eligible hotels, vacation rentals, flights, car rentals, and more when you book across our family of brands.
2. Hotel Ignacio - Saint Louis
Boutique hotels are often associated with the image of style, energy, and trendiness. This fancy 4-star boutique hotel in downtown St. Louis fulfills those three criteria, offering stunning guestrooms that look and feel fantastic.
Meet friends at the lounge and unwind with drinks while chatting by the lit fireplace. If you have a fitness routine to maintain or excess energy to burn, hit the on-site gym and use their exercise equipment. After hitting the town, you can grab a nightcap at the on-site bar before heading off to your plush bed.
Hotel Ignacio - Saint Louis
Address: 3411 Olive Street, Saint Louis Downtown, St. Louis (MO), United States, 63103
2.37 km (1.5 mi) from Cathedral Basilica of Saint Louis
3. The Last Hotel (from USD 150)
The 4-star boutique hotel near St. Louis’ city center promises a relaxing stay. It welcomes business travelers and vacationers. Cozy rooms, suites, and VIP suites are available to help you stay leisurely. The plush hospitality facility is in a former International Shoe Company building. Moreover, this place has metalwork, stone carvings, and terrazzo floors boasting Art Deco and Neoclassical styles and shoemaking-inspired details. If you love Italian food specialties, relish Italian culinary delights at the on-site restaurant Ultima Cucina.
The exclusive The Last Rooftop invites you to dip in the rooftop pool. You can also enjoy your favorite drink at the rooftop bar. Business travelers can even find meeting space helpful to conduct seminars.
The Last Hotel
Address: 1501 Washington Ave
4.84 km (3.1 mi) from Cathedral Basilica of Saint Louis
Top guest reviews
Cleanliness:
very nice people beautiful clean room with great viewsthe room itself was so cozy and cleanRead more reviewsHost:
my entire stay was wonderful thanks to the attentive staff
4. Moonrise Hotel (from USD 151)
Rest your weary feet in this wonderful hotel. It boasts a fantastic mix of contemporary design and eccentric sophistication that will charm you. You get to stay in well-furnished rooms and use eco-friendly amenities. Besides boutique rooms, you can also find celebrity suites. Savor soul-satisfying American delicacies at the on-site dining facility Eclipse Restaurant.
Later, you can head to St. Louis Rooftop Garden Bar and enjoy cocktails and refreshments under the largest man-made moon on the globe. Moreover, the hotel boasts a top-notch fitness center to help you stay in shape.
Moonrise Hotel
Address: 6177 Delmar Blvd
4.1 km (2.6 mi) from Cathedral Basilica of Saint Louis
Top guest reviews
Cleanliness:
room was clean and spaciousHost:
everyone we encountered on the property was friendlythe bartender up there was so friendly and accommodatingRead more reviewsLocation:
liked the location (not to far from the airport)Earn OneKeyCash for every dollar spent on eligible hotels, vacation rentals, flights, car rentals, and more when you book across our family of brands.
St. Louis Tour Guide
Melissa Smith
I began my guiding career as a teenager in St. Louis, where I was born and raised. I first volunteered as a guide for the Chatillon-Demenil Mansion in South St. Louis. There is where I fell in love with history and its effect on present day. From my teenage years as a volunteer, I progressed to a job at the Missouri Botanical Garden where I trained and supervised the School Program Volunteer Do... Read more
Tours by Melissa
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5. Angad Arts Hotel (from USD 134)
Enjoy an unforgettable stay in a room of your choice of color in this luxury boutique hotel in St. Louis. It boasts artfully decorated rooms and suites in various hues, including red, green, blue, and yellow. Begin your day by relishing breakfast in the Atrium. You can enjoy savory European food specialties for meals at the restaurant—Commonwealth.
You can continue your workout routine at the on-site fitness center, which is open 24 hours. You can enjoy crafted cocktails while watching views from the ART Bar Rooftop.
Angad Arts Hotel
Address: 3550 Samuel Shepard Drive
2.15 km (1.4 mi) from Cathedral Basilica of Saint Louis
Top guest reviews
Amenities & Room:
needed better lighting in the roomRead more reviewsHost:
the employees was very nice and helpfulstaff was phenomenal friendly and helped solve a significant personal issue quicklystaff were wonderful location was great
Indulge in leisure holidays in St. Louis
St Louis promises unlimited fun, adventure, and relaxation opportunities. Staying in a cozy hotel will help you relax and get re-charged for another exciting day. Pack your bags for a refreshing break, and book one of these best boutique hotels in St Louis, Missouri.
Frequently asked questions about boutique hotels in St Louis, Missouri
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