The scenic city of Greenville is nestled at the bottom of Blue Ridge Mountains. It’s home to several parks that highlight the area’s abundant natural beauty. Falls Park on The Reedy is its most popular one and is an unmissable attraction of the city. Exploring Greenville Health System Swamp Rabbit Trail, which is a 22-mi (35-km) trail system that runs along Reedy River, is also a must for outdoor lovers. Greenville Zoo, Upcountry History Museum and Greenville County Museum of Art are other good places to check out as well. If you’re travelling as a family or a large group, you’ll probably appreciate having spacious stay options. If you want extra room to spread out, check out the best 2-bedroom hotels in Greenville, South Carolina, below.
We handpicked these listings carefully, considering (wherever possible) recent guest reviews, location, accommodation type, prices, availability of dates, decor, and access to two bedrooms. The image galleries get refreshed with the latest updates regularly. They were last updated on February 15, 2025.
1. Residence Inn by Marriott Greenville Downtown (from USD 518)
With its apartment-style suites, this hotel in the downtown area is an ideal choice for those seeking ample legroom. The hotel’s two-bedroom suites provide different configurations to choose from based on your needs. One type has king-size beds in both bedrooms, while another provides one king and one queen bed.
Moreover, floor-to-ceiling windows showcasing lively city views add appeal to the accommodations. Since the rooms offer full kitchens, you can easily put together your favourite meals if you aren’t keen on hitting up nearby restaurants.
Residence Inn by Marriott Greenville Downtown
668 meters (0.5 ft) from Falls Park on the Reedy
Other 2-bedroom accommodations in Greenville, South Carolina
2. Characterful rental near downtown (from USD 186)
This two-bedroom rental unit has wooden flooring and cheery furnishings that make it feel welcoming. It offers two bedrooms spacious enough to accommodate a total of four persons. Both rooms offer plush queen beds to ensure guests get a good night’s sleep.
Meanwhile, the kitchen comes fully equipped for all your cooking needs. Another added perk is the large fenced backyard with a deck where you can laze around, barbeque some meat, or just play with your pet.
Top guest reviews
Host:
the management was mostly responsive if a little slowthe owners are very nice and quick to respond to questionsthe owners thought of everything super accommodatinghouse was perfect but neighborhood needed some renovation and updates the staff was outstanding; very helpfulconoly and matt are lovely people and very accommodatingLocation:
love the location and the neighborswe had a great time the location is close to everythingthis is a great little house with great locationgreat location and the house was very cleanthe home is located close to great foodCleanliness:
first of all let me say that the property was clean and comfortableRead more reviewsAmenities & Room:
beautiful and well kept home the beds were super comfy toowe found the cottage to be very comfortable for the two of us
3. Comfy rental with simple interiors (from USD 105)
This property sits within a quiet neighbourhood just three minutes away by car from downtown Greenville. Offering home-style comfort, the rental provides two bedrooms, one of them with a queen-size bed and the other with a king. Additionally, the living room with a flat-screen TV is a great place to wind down after busy days. A fully equipped kitchen with eat-in facilities and a patio comprise its other features.
Top guest reviews
Host:
owner was very responsiveowner was friendly and accessibleowner was very easy to work with and very accommodatingomar was very responsive and friendlyLocation:
very close to downtown greenville and many attractionsgreat place to stay very close to the convention centerthis property was in a good locationhad everything we needed and was close to downtown points of interest tooi am so happy i found this cute little placeCleanliness:
inside was very clean and pleasantsuper clean great communication with the ownerproperty was small but cleanwe enjoyed our stay it was very clean insidegreat place near downtown clean comfy and pet friendly plus very responsive hostRead more reviewsAmenities & Room:
couldn’t connect to wifi watch tv but otherwise everything was greatthe charming cottage was very clean the furniture was modern and very comfortable
4. Posh townhouse with dedicated parking spots (from USD 437)
This rental in the city’s West End offers an enviable location. A two-minute walk will find you before major downtown attractions, such as Falls Park on the Reedy and Main Street.
The property is beautifully appointed and spread over two levels. It offers two bedrooms with king beds and smart TVs so that you can decompress comfortably at night. There’s also a futon in the living room if you need additional sleeping space. Moreover, the living room opens to a fully equipped kitchen and has ample relaxing space. The small furnished patio at the back of the house ensures you can enjoy the pleasant weather and barbeque meals.
Top guest reviews
Host:
host was super responsive to our questionsi appreciate the owner’s thoughtfulness and attention to detailthe owner responded quickly and also had all info needed in a binder which was helpfulthe communication with the owner was great as well he answered any questions we had fastvery nice and friendly i highly recommend themLocation:
location is great within walking distance to many placeslocation fabulous and a great property for petsfantastic location to get to restaurants in west end very comfortable space and quiet streethope to come back to this place againit has unquestionably the best location to enjoy falls creekCleanliness:
great communication and very cleanthe condo is beautiful very clean and quieteverything in the house is clean and in working orderhunter's townhome was accurately describes and very cleanRead more reviewsAmenities & Room:
the beds- a queen and a king- are comfortable
5. Bright rental with polished wood floors (from USD 154)
Well lit and airy, this single-level house close to downtown makes an excellent base for your trip to Greenville. Stylish touches, such as wooden flooring and antique furnishings, give this house an air of elegance. Additionally, premium bedding ensures a good night’s sleep, while other amenities, such as high-speed WiFi and a 36-in (92-cm) smart TV will keep you entertained. When it comes to sleeping arrangements, there are two bedrooms set up with king beds that you can jump into after a day of exploring the city centre.
The rental also has a large fenced backyard that includes a wooden deck with a grill for outdoor recreation, relaxed evenings and al fresco meals.
Top guest reviews
Host:
owners did a great job communicating and stocking the housea+ the host were great and welcominglove the owners who have become dear friends through the years we’ve visited greenvilleLocation:
great location and very cozynice cozy place close to plenty of fun stufflocation was great neighborhood felt safe and we had everything we neededthis charming house was perfect for me my hubby and our pups it’s located in a quiet neighborhoodCleanliness:
bathroom was a bit small but cleanRead more reviewsAmenities & Room:
the wifi and cable were excellentwe were able to cook in the well stocked kitchen and enjoyed dining both indoors and outwe enjoyed our stay in greenville and the cozy cottage
6. Chic condo in historic district (from USD 105)
This snug condo is situated in one of Greenville’s charming historic districts, Colonel Elias Earle Historic District, and its mid-century styling creates an ambience of quiet elegance.
The rental’s living room, which has a large TV, is a wonderful spot for unwinding after a day of exploration. Its well-equipped kitchen makes sure you can rustle up meals on demand. You will also find two cosy bedrooms here, one with two twin beds and the other with a king bed. Other added perks, such as complimentary breakfast, WiFi and concierge service, make this rental comparable to a hotel.
Top guest reviews
Host:
easy process and communicative owner is alway niceLocation:
this condo is in a great locationann's condo is on a nice quiet street within walking distance of downtownnice place great location and perfect ownerit’s a nice neighborhood for evening walks where everyone says hiin fact it was probably the best stocked place i've ever stayed inCleanliness:
condo was very clean& safeyour condo was clean and comfortable for a short or long term staya very clean and comfortable condo my husband and i enjoyed staying thereit was well stocked and cleanit was well stocked and super cleanRead more reviewsAmenities & Room:
the tv and internet were great and the furnishings finenice little apartment- perfect for a visit to greenvillethere were definitely moments we wanted an extra bathroomgreat space with lots of room in the master bedroomloved the historical neighborhood the apartment was in
7. Plush loft on Main Street (from USD 449)
This rental’s unbeatable location right on Main Street makes it a natural choice for those looking to be in the thick of the action. With exposed brick walls and high ceilings, the property exudes class and style. The expansive living space provides a romantic area to hang with your partner, and there’s even a grand piano if you want to indulge in some music. Also, a small kitchenette on one side of the room provides the basics for when you want to eat in.
This stunning rental has two bedrooms with one king bed and one queen bed, but you’ll also be able to request two additional beds if you require the space.
Top guest reviews
Location:
beautiful location and aptthis was the perfect location for downtown greenvillesuper location for us to walk to all we did in greenvillethe location is superb being right on main street and having several shops and restaurants so closegreat location if you want to be in the center of everythingRead more reviewsAmenities & Room:
we rented in the middle of july and the apartment didn’t cool below 74 degrees
8. Charming and colourful home with expansive porch (from USD 105)
Once a mill house, this quaint home is now a modern space that can comfortably host up to five persons. It provides two bedrooms—the master bedroom offers a queen and a single bed, while the other offers another single. The sofa in the living space can also be converted into a bed should you require it. Additionally, the fully stocked kitchen provides all the essentials along with eat-in facilities.
Make the most of the property’s proximity to Greenville Health System Swamp Rabbit Trail and Unity Park with biking or hiking excursions. The rental helpfully offers bikes for guests’ use.
Top guest reviews
Host:
the host was extremely responsive to questionslots of little touches that show that the owners really care about their tenants—little snacks sodas and toiletriesthe house was very cutely decorated and comfortable and our host was extremely helpful and transparentwe loved the house the location was perfect and the owner is lovelyLocation:
nice place for the moneyCleanliness:
so clean and convenient to everythingplace was very cool(temperature wise—important in the summer in sc ) and cleanRead more reviewsAmenities & Room:
the wifi and hvac worked great
9. Upscale townhouse with ample amenities (from USD 250)
This townhouse in the West End area has a wonderful location close to downtown. Cosy up before the fireplace in the living room to wrap up a day of exploring Greenville. The property offers two bedrooms both located on the upper level. You will find a king bed in one and a queen bed in the other. Both rooms have TVs with cable for bedtime entertainment. There’s also the option of using the sofa in the living space as a bed if required.
Furthermore, the house is chock-full of convenient amenities, including a full kitchen, free WiFi and laundry equipment. Its small back patio, set up with barbeque facilities, is great for leisurely evenings outdoors.
Top guest reviews
Host:
owners very responsive and accommodatingthe owners take excellent care of their townhome and customersthey are also very responsive and pleasant to communicate withLocation:
awesome location with ample parkingand the location location location was simply ideal to all the great restaurants and shops to downtownyou can walk to main street through the lovely falls parkthe location was our favorite featurewe loved this little condo located next to falls park on the reedyCleanliness:
we stayed for 2 weeks and the unit was very clean comfortable and quietthe townhouse itself is very clean functional and well stocked in everything you can imagine one’ll needthe townhouse is very well maintained clean and in a great locationRead more reviewsAmenities & Room:
the beds and furniture are all very comfortable
10. Homewood Suites By Hilton Greenville Downtown (from USD 269)
Excellent breakfast with versatile options, though some minor room for improvement
Reasonably priced with free breakfast and private parking
Perfect downtown location near Falls Park on the Reedy, restaurants, and baseball field
Spacious rooms with kitchenette, modern decor, pool, and friendly staff
With its prime location close to downtown Greenville, this all-suite hotel ensures you’re within quick reach of the city’s hotspots.
Its two-bedroom suite was designed to comfortably accommodate up to up eight guests. One bedroom comes with two queen-size beds, while the other features a king-size one. Each also has an en suite bathroom. In addition, there’s a separate living space that includes a fully equipped kitchen if you want to cook your own meals. Complimentary WiFi access will also make it easy to remain connected during your stay.
Homewood Suites By Hilton Greenville Downtown
687 meters (0.5 ft) from Falls Park on the Reedy
Roomy stay options curated for you
Cramped hotel rooms can dampen the mood while travelling, especially in an adventure-filled city like Greenville. Instead, check out this list of the best 2-bedroom hotels in Greenville, South Carolina, so that you can easily select the best option for you.
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