Durham is a city with a laid-back but ready vibe. Its most well-known area is arguably Duke University, one of the top colleges in the country. You can give yourself a tour around campus and admire the historic structures. While there, make sure to pay a visit to Sarah P. Duke Gardens, named after the wife of Benjamin Duke, one of the benefactors of the university. Duke Lemur Center, home of animals such as lemurs, tarsiers, and lorises, is also worth checking out while on campus. If you want to learn about the area’s history, head to Bennet Place Historical Site, which has a museum that houses artifacts from the Civil War. You can also get tickets to catch a show at Durham Performing Arts Center.
Planning to spend a comfortable holiday in the city? Choose one of the best hotels with 2 bedrooms in Durham, North Carolina, from this list.
We handpicked these listings carefully, considering (wherever possible) recent guest reviews, location, accommodation type, prices, availability of dates, decor, and access to two bedrooms. The image galleries get refreshed with the latest updates regularly. They were last updated on April 24, 2025.
1. Residence Inn by Marriott Durham-Research Triangle Park (from USD 110)
Both rooms in the two-bedroom suite of the cozy Residence Inn by Marriott Durham-Research Triangle Park are furnished with queen beds for guests’ comfort. The two rooms are connected by a sitting area equipped with a work desk. The unit includes a full kitchen so you can prepare your own meals. There’s also a fireplace installed to give the room a cozy vibe. The suite has three TVs so you and your companions don’t have to fight over the remote.
One crib can be requested if you’re traveling with an infant. Note that this is a non-smoking option.
Residence Inn by Marriott Durham-Research Triangle Park
Address: 201 Residence Inn Boulevard
11.36 km (7.1 mi) from Sarah P. Duke Gardens
2. Homewood Suites Raleigh-Durham Airport (from USD 145)
Homewood Suites Raleigh-Durham Airport is worth considering if you’re flying into the city with your family or friends, as it offers a free airport shuttle. Its two-bedroom offering features a king bed in one room and two queen beds in the other. Two bathrooms can be found in the unit for your convenience.
The unit has a well-equipped kitchen furnished with amenities such as a stove, a refrigerator, and a dishwasher so you can prepare meals and clean up easily. A coffee maker is there for you to fix a cuppa before brewing the newspaper delivered to your room. Self-laundry is an option in this hotel if you want to wash your clothes.
Homewood Suites by Hilton Raleigh-Durham AP\/Research Triangle
14.79 km (9.2 mi) from Sarah P. Duke Gardens
3. DoubleTree Suites by Hilton Raleigh-Durham (from USD 122)
DoubleTree Suites by Hilton Raleigh-Durham comes with tastefully furnished suites perfect for families. The two-bedroom suite, which sleeps six, features a kitchenette equipped with a mini-refrigerator, a microwave oven, and a coffee maker. A king bed and a whirlpool tub in the ensuite bathroom are perks you will enjoy if you choose the master bedroom. The second bedroom, meanwhile, has two double beds.
The seating area is furnished with a sofa sleeper if you need more space to get some rest. A TV is available in each room for you to kick back and watch a show or a movie in your downtime. There’s also a desk you can use if you need to work. Complimentary remote printing is offered to guests.
DoubleTree Suites by Hilton Raleigh - Durham
10.72 km (6.7 mi) from Sarah P. Duke Gardens
Other 2-bedroom accommodations in Durham, North Carolina
4. Historic downtown home with a minimalist touch (from USD 210)
This house sits on a hill and is within walking distance of grocery stores and restaurants. The sunny master bedroom comes with an ensuite bathroom and a comfy queen bed. The laundry area is also accessible from there. The spacious second bedroom, meanwhile, comes with two queen beds. A shared bathroom can be used by guests staying here.
The house has a full kitchen that you can use to prepare your specialties, which you are free to enjoy in the dining area. The backyard is fenced to guarantee privacy if you wish to hang out there.
Top guest reviews
Read more reviewsLocation:
great house ideal location immaculate condition well equipped easy walk to restaurants etcscott's place is even more beautiful than it looked in the pictureslovely location newly renovated peaceful inside / outside and with historic charmwonderful location super clean very awesome stay
5. Newly renovated home in the Walltown neighborhood (from USD 65)
This newly renovated rental is well-equipped for a comfortable stay. It has two bedrooms, which are equipped with queen beds and air conditioning for restful nights. The rental is furnished with amenities to make you feel right at home. Modern appliances have been installed in the home, including those in the up-to-date kitchen. The property also has a washing machine in case you need to do your laundry.
Off-street parking is available at the back of the house. The house is in a popular neighborhood that puts you just a short walk away from restaurants, a playground, and Duke University.
Top guest reviews
Host:
from start to finish he was a great host and the space was clean and peacefulRead more reviewsLocation:
the location is great; close to everything
6. Duplex apartment close to restaurants (from USD 97)
Foodies and social butterflies will want to book this option as it is within walking distance of good restaurants, as well as entertainment. If, however, you prefer to prepare your own food, the duplex apartment has a well-equipped kitchen that you can use to cook up a storm.
Both bedrooms in this apartment have queen beds. Linens, pillows, and blankets are provided for your convenience. The bedrooms also feature pristine white furnishings to create a bright and spacious vibe. If you’re driving to Durham, there’s space for one vehicle on the driveway. Street parking is also available if your group is bringing two or more cars.
Top guest reviews
Host:
awesome host quick response & great communicationLocation:
great location walking distance to food & entertainmentvery inviting place conveniently close to the happenings in the cityif you are looking for a quiet place in a great location then i highly recommendgreat location place and host a few minutes walk from coffee food and entertainmentexcellent host and perfect location to downtown and activitiesRead more reviewsAmenities & Room:
the duplex was very comfortable (beds and couch)
7. Downtown apartment with balcony
The two bedrooms of this tastefully decorated apartment are equipped with comfy queen beds and fresh linens. Closet space is available so you don’t have to worry about leaving your stuff lying around. The two rooms also have cute lamps to allow light reading before bedtime. The exposed brick walls only add charm to the property. Additionally, the rental is equipped with air conditioning and heating to help you stay comfortable no matter the weather.
This property sits right in the downtown area of Durham, making it easy for you to reach local restaurants and shops even on foot.
Durham, North Carolina, United States
2.3 km (1.5 mi) from Sarah P. Duke GardensAccommodates: 4
Top guest reviews
Location:
great location and walking distance from many thingsexcellent location walking distance to cafes and bars areathe apartment was in the perfect location easy to walk to restaurants bars and the farmers marketthere is access to walking / bike trails excellent restaurants and parksgreat apartment in walking distance to east campus or downtown durhamCleanliness:
quiet clean apt with 2 roomsclean and host very responsive will be backthe apartment was very clean and well appointed and had everything we needed in the kitchenRead more reviewsAmenities & Room:
nicely furnished and cozy
8. The Trifecta (from USD 58)
History lovers will adore The Trifecta, a loft apartment in an 18th-century building. The bricks on the building’s exterior are also featured in some internal sections of this rental, creating a unique vibe. Its two bedrooms are charming, each featuring a comfortable queen bed and a character of its own. Room darkening shades are installed to help you protect your privacy. Speedy WiFi can accommodate your personal or professional requirements. Paid laundry facilities can also be found down the hallway.
This property sits on Morgan Street, making it easy for you to reach Durham’s commercial establishments. Free on-site parking is available here.
Top guest reviews
Host:
they were always responsive via message but seemed to put in minimal effort to resolve issuesi've stayed with this host 3 times already and have enjoyed each visitcheck-in and check-out was super easy thanks to the guidebook the host provided with detailed instructions and photosthe people in the building are friendly and we were able to enjoy without any complaints etcgreat stay very responsive used to wfh in a new environmentLocation:
great location walk to food and entertainmentclose to everything safe areathe place was nice the location was goodit was a great location for the family to stay for my graduation from duke universitygreat place close to local places and super easy to access all areasCleanliness:
super clean super easy and communication was a breezethe beds were clean and comfortablegreat space - clean and safeclean and exactly what we were looking forlovely clean and very convenientRead more reviewsAmenities & Room:
we also really enjoyed the amenities included like the 2 pools and gym we had a great stayexpect a lovely stay is an open air apartmentwould recommend for sleeping only as the beds were very comfortableliving room space could use a more comfortable seating piece
9. Relaxing home with fenced yard (from USD 456)
This beautifully decorated rental actually comes with three bedrooms, but the third room has been converted into an office that you are welcome to use during your stay. The other two sunny bedrooms, meanwhile, have cozy queen beds where you can rest after a busy day. The host can also provide an air mattress, which can be set up either in the office or in the living room.
Up to two pets are welcome on this property, and they will have fun zooming around the spacious fenced backyard. The host can recommend a dog walker if you need someone to help you with your fur baby’s daily exercise - this service comes with an extra fee.
Top guest reviews
Host:
the hosts communicated quickly and were very friendlybeautiful updated home with attention to detail by ownersLocation:
the location was perfect to various places in durhamthis was such a perfect place to stayquiet neighborhood and felt safeCleanliness:
clean comfortable bed fantastic showerit was clean and everything was of great qualityit's clean well organized and the hosts were very responsivethe house was cute and cozy with cleanliness being on pointRead more reviewsAmenities & Room:
comfortable beds & excellent snacks & coffee
10. Charming home in quiet cul-de-sac (from USD 111)
Light sleepers will want to consider this property as it sits in a quiet neighborhood, so they are guaranteed a good night’s rest. One bedroom in this rental has a double bed while the other one is furnished with a sofa bed. Room darkening shades provided in each bedroom further make this rental a great spot to rest and recharge. You will also find ample closet space in each bedroom. Infant-friendly amenities such as a travel crib, a high chair, and a changing table may be provided for guests with babies.
Music lovers can take advantage of the piano provided. Feel free to use the kitchen to prepare your favorite dishes. Long-term guests can be accommodated on this property.
Top guest reviews
Host:
she quickly responded to my questions and was very helpfulgreat place quiet clean and the owner sally very accommodating and a sweetheart thank you againLocation:
sweet place in a quiet locationsally's place is a great location and a lovely place to staysally’s place is in a great location-10 min to downtowngreat rental location and communicationthe house itself is nicely decorated quiet and comfortable - and close to everythingCleanliness:
clean and exactly as listedcozy and clean both rooms have a full size bedit was clean and comfortable with easy check in/outsally’s place was clean spacious and a 10 min drive to downtownthe stay is clean easy; clear instructions provided by sallyRead more reviewsAmenities & Room:
wifi speeds were good for streaming and wfh
Experience the unique vibe of Durham
Durham is a city with a unique character, combining urban energy with a laid-back vibe. Stay in one of these accommodations if you are planning to visit the city with some company and have a great holiday!
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