With warm and welcoming locals and a blend of small-town charm and big-city lifestyle, Florence is a quintessential southern city. It has a lot to offer tourists, be it in terms of dining, entertainment, or recreation. At the nearby Lynches River County Park, located 21 minutes away from Florence, you can enjoy a breath of fresh air while the kids run around. You can also paddle around South Carolina Revolutionary Rivers Trail to explore a significant piece of local history. You can later catch a show at Francis Marion University Performing Arts Center if you like live performances. If you need spacious accommodations during your trip with your family and friends, you may want to stay in the appropriate accommodation. Check out the top hotels with 2 bedrooms in Florence, South Carolina below.
We handpicked these listings carefully, considering (wherever possible) recent guest reviews, location, accommodation type, prices, availability of dates, decor, and access to two bedrooms. The image galleries get refreshed with the latest updates regularly. They were last updated on October 30, 2025.
1. Staybridge Suites Florence - Civic Center, an IHG Hotel (from USD 174)
Strategically positioned in the city, Staybridge Suites Florence - Civic Center, an IHG Hotel is only a short walk from Magnolia Mall and numerous restaurants, so you will have lots to explore. It also has a seasonal outdoor swimming pool, allowing you to enjoy a relaxing dip. Later, indulge in the free breakfast served here.
You can also easily have cookouts, thanks to the grilling pavilion. For large groups, the 1 King 2 Queen 2 Bedroom Suite is an excellent choice. Sleeping up to eight people, besides the comfy bed, it also features a seating and dining area as well.
Staybridge Suites Florence - Civic Center by IHG
Address: 150 Westpark Drive
6.73 km (4.2 mi) from Timrod Park
2. Residence Inn Florence (from USD 141)
Residence Inn Florence only has 94 tastefully decorated guest suites, so you can expect attentive hospitality in a peaceful environment. It offers these suites in various types, including the Two Bedroom Suite. Accommodating a maximum of six people, it features a master bedroom with a king-size bed and a bedroom with a queen-size bed. For extra sleeping space, a sofa bed is also available. Additionally, this hotel offers a 24-hour business center and free internet access for those traveling for work.
Residence Inn Marriott Florence
Address: 2660 Hospitality Blvd
5.87 km (3.7 mi) from Timrod Park
3. Hotel Florence, Tapestry Collection by Hilton (from USD 146)
Nestled in the downtown area, Hotel Florence, Tapestry Collection by Hilton is only 15 minutes from Florence Regional Airport. It provides complimentary parking, so you have nothing to worry about if you wish to bring a car. This pet-friendly hotel offers spa services too.
The Two Bedroom Owners Suite and Two Bedroom Penthouse Suite are perfect for large families or groups. Each guest suite sleeps up to six guests. In each suite, you will also find one bedroom with a king-sized bed and another with two queen-sized beds.
Hotel Florence, Tapestry Collection by Hilton
Address: 126 W Evans St
1.43 km (0.9 mi) from Timrod Park
Other 2-bedroom accommodations in Florence, South Carolina
4. Stylish home with a porch (from USD 176)
This stylish home has everything you need for a comfortable stay. Sleeping a maximum of five people, it offers two bedrooms. One has a queen-size bed, while another has a queen-size and a twin bed. Furthermore, thanks to the fully functional kitchen, you can quickly prepare home-cooked meals for your loved ones. In the mornings, you can enjoy your coffee on the porch and bask in the tranquility. Pets are even welcome here, so feel free to bring your four-legged friends.
Florence, South Carolina, United States
1.17 km (0.8 mi) from Timrod ParkSuperhost
Accommodates: 5
Top guest reviews
Host:
the host was friendly and responsivegreat space great hosts thank youaron and collin are perfect hoststhey always wrote back immediately and were super kind and courteous hostsit had everything we needed and communication with the host was easyLocation:
super close to i-95 exitwe had a great stay it is close to the highway and storesloved my stay at this adorable cottage in walking distance to florence's charming downtownplenty of great nearby restaurants quiet clean and close to the highwayvery clean and cute cottage great location just off i-95Cleanliness:
everything was very cleanclean and nicely decorated historical homethis place is very clean and nicely furnishedhouse is clean and adorably decoratedit is a very quaint clean and comfortableRead more reviewsAmenities & Room:
the kitchen is well-equipped and we appreciated the bottles of water left for us on the countercomfortable space for our family of 4the bed was comfortable and the bedroom was cozythe bed was very comfortable after my 6-hour drive highly recommend staying herethe kids room was perfect size for all 3 kids
5. The Beverly Bungalow (from USD 148)
If you are in the city for a few weeks or months, you can stay in this charming bungalow. It is available for monthly bookings. This rental accommodates up to five guests, with each bedroom featuring a cozy queen-size bed. Also, the sofa in the living room provides an extra sleeping space if needed. Furthermore, the paved driveway has parking space for one car, so you can park your car at no additional cost if you plan to bring one.
Florence, South Carolina, United States
1.48 km (1.0 mi) from Timrod ParkAccommodates: 5
Top guest reviews
Host:
great location in florence spencer was very accommodating and easy to work withLocation:
this house was the perfect location in a nice neighborhoodRead more reviewsCleanliness:
very clean and well-appointedthe house was very clean and check in instructions were very easy
6. Home with a fully equipped kitchen (from USD 504)
This home is suitable for small families or groups, and it offers two bedrooms. It has a master bedroom with a king-size bed and another room with a queen bed. Because of the complimentary onsite parking, parking will be the least of your worries if you intend to bring your car with you.
Additionally, a fully equipped kitchen is available, so you can indulge in your culinary pastime whenever you want. You can also do your laundry while here, as a washing machine and dryer are provided for your convenience.
Florence, South Carolina, United States
4.74 km (3.0 mi) from Timrod ParkAccommodates: 4
Top guest reviews
Read more reviewsAmenities & Room:
if in florence do yourself a favor and treat yourself to a cozy stay here
Maximize your trip to Florence
Florence gives you a taste of quintessential southern hospitality. As you plan your visit, check out these top hotels with 2 bedrooms in Florence, South Carolina! Stay in comfortable accommodation that checks all your needs for a memorable vacation.
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