South Carolina has a rich history that is evident with the well-preserved attractions you can find in this state. Lying in the southeastern seaboard of the United States, this region also makes for a great beach destination. Whether you want a low-key beach or one that is bustling with activities, beautiful beaches such as Edisto Beach and Myrtle Beach await you here. History buffs may want to visit South Carolina State Museum in downtown Columbia. On the other hand, if you want to wander through streets that merge history with the modern lifestyle, Charleston Historic District is the place to be. Narrated carriage tours are also available here, so you can learn about the city’s exquisite history while indulging in beautiful architecture.
If you are planning a hassle free visit to the state for the weekend, then keep on reading for the best adults-only all-inclusive resorts in South Carolina, USA.
We handpicked these listings carefully, considering (wherever possible) recent guest reviews, location, accommodation type, prices, availability of dates, decor, and adults-only all-inclusive packages and amenities. The image galleries get refreshed with the latest updates regularly. They were last updated on October 27, 2025.
1. Hilton Head Health - Weight Loss Resort and Health Spa; Hilton Head Island
Editor's Note: Photo taken from the establishment's official social account
After 40 years of providing residential wellness and weight loss programs, Hilton Head Health is excited to announce the...
Posted by Hilton Head Health on Saturday, February 1, 2020
This unique all-inclusive resort for adults is your partner towards life-long wellness. From personal trainers to professional nutritionists, you will be guided step-by-step in this weight loss resort and wellness spa for you to achieve your goals. Be motivated as you join fitness classes, wellness lectures, biking adventures, and beach walks. You can also utilize the resort credits included in your stay to avail of individual counseling or cooking lessons.
After completing the day’s schedule, bask in the glory of a serene location while you’re here. You can choose between a suite at Sweetgrass Inn or your own private villa, which is recommended if you’re planning on staying longer.
This all-inclusive resort includes meals and snacks, so you won’t have to worry about meal preping during your stay. Guests here can also make use of the complimentary roundtrip airport transportation.
What's included in the packages
Food: Included
Transport: Included
Activities: Included
Hilton Head Health - Weight Loss Resort and Health Spa
Address: 14 Valencia Rd, Hilton Head Island, SC 29928, United States
Price: from 663 USD
Star Rating: 4-stars
Travelers Review: Excellent 4.8(from 62 reviews)
Other adults-only accommodation with packages
2. Water's Edge Inn - Adults Only; Folly Beach (from USD 305)
A cozy yet elegant stay awaits you at this beautiful bed and breakfast a few blocks from the beach. Staying here includes spacious guest rooms and wonderful amenities, such as access to an outdoor hot tub, daily gourmet breakfast and happy hours. A complimentary shuttle service has been provided for you to conveniently access the beach and local restaurants.
Water’s Edge Inn - Adults Only also offers several romance packages that may include a couples massage, sunset sail, or paddle boarding, depending on the package you wish to select.
What's included in the packages
Food: Included
Transport: Included
Activities: Included
Water's Edge Inn - Adults Only
Address: 79 W 2nd St
13.92 km (8.7 mi) from Palmetto Carriage Works
Head to South Carolina for a peaceful vacation
There are times when you just crave a laid-back vacation to spend quality time by yourself or with your loved ones. South Carolina has plenty of attractions that makes a perfect backdrop for the serene getaway you desire. Book one of these all-inclusive resorts for adults on your next trip to South Carolina for a complete experience!
History
Get Trip101 in your inbox
Unsubscribe in one click. See our Privacy Policy for more information on how we use your data