Top 15 Airbnb Vacation Rentals In Rochester, Minnesota - Updated 2022

airbnb rochester minnesota

Rochester is best known for being home to the popular Mayo Clinic, but there’s more to this vibrant city in Minnesota than this renowned health care company. Tour the historic Plummer House, try local wines at Salem Glen Winery, visit local parks such as Cascade Lake Park and Silver Lake Park, or explore Rochester Art Center. Besides these, there are so many other things to do in Rochester, so you’re unlikely to get bored. Plan your trip today and book any of these best Airbnb vacation rentals in Rochester, Minnesota for a cozy and convenient stay. Scroll down for more!

1. Charming house four blocks from Mayo (from USD 133)

This charming older house is located only four blocks from Mayo Clinic. The apartment has 2 bedrooms, a bathroom and well-equipped kitchen and the host welcomes weekend trips and extended stays. Free Netflix and Wifi is available, so you can rest assured that you will not miss your favorite TV show during your stay.

Cozy 2 Bd, 1 Bth 4 blocks from Mayo
Rochester, Minnesota, United States
104 reviews Superhost  Wifi Available
Entire rental unit 2 Beds 3 Guests 2 Bedrooms 1 Bathroom

Accommodates: 3

Top guest reviews
Amenities & Room:
the air conditioner is nice during the hot/humid months
it was very easy to connect to the wifi and use netflix on the televisions
the furniture and bed were comfortable and we did watch a little netflix
the bed was amazingly comfortable
the rooms were nicely painted and kitchen adequately stocked
clean well stocked apartment
it was clean and convenient
it was very clean and fresh
convenient and clean place to stay
very clean and a very quiet neighborhood
josh was a great host
josh is a great host
great host was very good about answering any questions and concerns we had
josh was a outstanding host and responded to all my questions and concerns quickly
josh was a very gracious host
great location & private parking
shopping especially for fresh produce and the hyvee is close by
i would definitely book this location again
parking was easy and great central location
easy walk to the clinic
Read more reviews

2. Quaint boutique home near Mayo (from USD 99)

Located on a quiet street, only a block away from Mayo Clinic, this unique boutique house will be your home away from home during your stay in Rochester. This beautiful accommodation in Rochester is a two-bedroom home that has been recently redecorated in a beautiful boutique style. Additionally, the hosts will provide during your stay bikes, free internet, Hulu, Netflix, and HBO. There is no way you will get bored here.

Quaint Boutique Home *NEAR MAYO*
Rochester, Minnesota, United States
258 reviews Superhost  Wifi Available
Entire home 3 Beds 6 Guests 3 Bedrooms 2 Bathrooms

Accommodates: 6

Top guest reviews
Amenities & Room:
plenty of space and very comfortable
misha & alex's place offered great furnishing along with extremely comfortable beds and a fully stocked kitchen
this was a wonderful place to stay for an evening a beautiful comfortable home with all the amenities
the beds were very comfortable
nice warm blankets and comfortable beds
everything was very clean
small kitchen but clean and functional
easy check in process clean many towels/washcloths etc
clean nicely furnished and easy to get to
this place was really clean and comfortable
they were very responsive to my questions
great space with helpful hosts
the hosts were absolutely wonderful and quick to respond to any questions/concerns we had
the hosts thought of everything loved all of the little touches
mischa and alex were wonderful hosts
cute house in quiet neighborhood and close to rochester attractions
location was excellent- quiet neighborhood but close to amenities
great value and a great location
perfect location less than 10 minutes to gonda bldg
great location if you are visiting mayo and have your own transportation
Read more reviews

3. St. Augustine loft near Mayo Clinic (from USD 62)

Choose this amazing upstairs sunny loft if you are looking for convenient and comfortable accommodation near Mayo Clinic. This Rochester vacation rental has a queen size bed, a private bathroom, a desk to read and a TV. Also, if you are arriving with a car, safe and convenient parking is provided by the owner.

St. Augustine Loft Mayo Clinic GARAGE!!
Rochester, Minnesota, United States
150 reviews Superhost  Wifi Available
Entire home 1 Bed 2 Guests 1 Bedroom 1 Bathroom

Accommodates: 2

Top guest reviews
Amenities & Room:
the bed and couch were super comfy
very comfortable living room nice chairs and sofa
the place had great wifi as well
the bed and couch were amazingly comfortable and the space was just perfect for us
the loft is comfortable quiet and full of natural light
everything was very clean and comfortable
clean quiet and convenient
it was very clean comfy and convenient
great place very clean and well equipped
the loft is exactly as advertised clean comfortable and safe
the host is attentive and kind
denise was an excellent host very friendly and great hospitality
great host and very good place with good privacy
the advantages of having a host who was a seasoned traveler are many
denise was a really kind and attentive host
the location provided very easy access to mayo
perfect location if going to mayo
close to large shopping centres and an easy 15-20 min walk to mayo clinic downtown
very nice little place and close to downtown
this place suited us perfectly
Read more reviews

4. Private room in house one mile from Mayo Clinic (from USD 49)

This private room is located in a beautiful house only five minutes away by car from Mayo Clinic. It is perfect for patients, students, couples or single travelers. In the room, you can find a queen size bed, a microwave, a mini fridge and a TV with DVD players. The house is decorated in a rustic modern style and you will be allowed to use the kitchen or the laundry upon request.

Private room in house 1 mile from Mayo Clinic
Rochester, Minnesota, United States
49 reviews  Wifi Available
Private room in home 1 Bed 2 Guests 1 Bedroom 1 Bathroom

Accommodates: 2

Top guest reviews
Amenities & Room:
the room and amenities were fabulous
the bed was so amazingly comfortable- you get a memory foam mattress with really nice and soft comforter
the room has a minifridge desk and other very nice amenities which helped make my stay here great
the room even included books and dvds and a tv though i hadn't the time to enjoy them
i really appreciated having a microwave refrigerator and tv
it was very clean
room was clean and well decorated
kristin's place is very clean quiet and kept
the room was very clean and nice
the room was super clean and comfortable
friendly hosts and pets
very nice home nice hosts
kristin is a great host who will make you feel at home
kristen was a great host
host answers questions quickly and is generous in sharing household items
great location only 3 minutes to get downtown
the location is wonderful everything you need is nearby
kristin was a great host & the location was perfect - super close to "downtown"
i was in town for a conference and it was an easy 1 mile walk to mayo
we had a great stay kristin was so accommodating and her house was very comfortable and close to everything
Read more reviews

5. Classy place (from USD 120)

This classically decorated home is conveniently located within walking distance from Mayo Clinic. Whether you are a weary patient or just a traveler, there is no comfort you will miss in this beautiful home. Bikes and helmets are provided for the adventurous bikers who are seeking cheap transportation or exercise. Also, if you are planning to stay longer, you can get a monthly discount.

Fully Furnished Home Walking Distance to Mayo!
Rochester, Minnesota, United States
42 reviews Superhost  Wifi Available
Entire bungalow 2 Beds 4 Guests 2 Bedrooms 1 Bathroom

Accommodates: 4

Top guest reviews
Amenities & Room:
kellie was very responsive when there was an issue with the air conditioning
nice apartment fully functional
the heating system was easy to use as well as the wifi the television and the dvr
it was exactly as described and the beds were very comfortable
amazing place clean and comfortable
great house very clean and comfortable
it was clean spacious and tastefully decorated and furnished/very comfortable
kellie’s is very cozy and clean
it was very clean & we appreciated the updated decor of the little red bungalow
kellie is a great host and the place is amazing
the stay was simply wonderful and kellie was an even better host
we enjoyed our stay and recommend this airbnb and host
we had a phenomenal stay and the hosts were incredibly kind and flexible with our requests
bekah was very kind and accommodating
excellent location at walking distance from mayo grocery stores restaurants and walking/running/cycling paths
the neighborhood is cute and the walk to mayo easy
walking distance to mayo as well as super market
location is another big asset: for mayo main campus you walk 15 min and st
just a 5 min walk through a nice neighborhood each day
Read more reviews

6. Private remodeled apartment (from USD 70)

Enjoy staying in a cozy and newly renovated apartment big enough for three guests in the heart of Rochester. They will be sleeping in a queen-bedroom, with high-quality sheets and linens for a good night’s rest. There’s also a bathroom with a tub, and toiletries provided for guests’ convenience, a full kitchen, and a living room with tasteful decors and functional interior. Entertainment can be found in a smart flat-screen TV with access to Netflix, Hulu, HBO, and Amazon to name a few. There’s also air conditioning, heating, free parking, a patio, a balcony, overlooking the garden. This flat is located in a quiet neighborhood, great for family travelers, and just close to the downtown hub where all the best dining and top shopping malls are.

Private cozy apartment *NEAR MAYO* Remodeled!
Rochester, Minnesota, United States
419 reviews Superhost  Wifi Available
Entire rental unit 1 Bed 3 Guests 1 Bedroom 1 Bathroom

Accommodates: 3

Top guest reviews
Amenities & Room:
the living room was comfortable with a tv that provided free netflix
they have an easy to access space that is stylish and comfortable
i really appreciated the fully equipped kitchen because i was cooking my own food
the bed was very firm so please keep that in mind if you like a softer bed
great place with a bedroom den and kitchen
very clean and roomy
clean and well stocked
very clean and tastefully decorated
great looking place and very clean
the place was clean and comfortable
hosts were great
great hosts very responsive to any questions or needs i had
super attentive and kind hosts
alex was was accomadating and friendly host and quick to respond to any questionsor needs
they are amazing hosts that care for your airbnb housing experience
the location was ideal very close to the downtown
very cute and a great location
nice and close to mayo
great location for mayo visits
location is great and within walking distance to downtown/mayo civic center
Read more reviews

7. Cozy basement flat with a fireplace (from USD 45)

Located in the Kutsky Park neighborhood, this quiet and safe area is great for families traveling to Rochester. Guests of two are welcome to stay in this cozy basement apartment, complete with everything you when in Rochester. There’s a stylish double bedroom, a clean bathroom with provided toiletries, a full kitchen with updated cookware and appliances, as well as wifi access and a flat-screen TV for entertainment. A free street parking spot is available outside the house and access to a private garden backyard. Apart from charming interiors, there’s also a fireplace, great for cozy and romantic nights indoors.

Cozy, comfy 1 BR unit in triplex, 4 blocks to Mayo
Rochester, Minnesota, United States
148 reviews Superhost  Wifi Available
Entire rental unit 1 Bed 2 Guests 1 Bedroom 1 Bathroom

Accommodates: 2

Top guest reviews
Amenities & Room:
wonderful apartment just as described
the bed is incredibly comfortable
the ability to do laundry on the premises for a multi-night stay was also a great convenience
the aspect of the apartment that i liked most was the electric fireplace
terri's place was incredibly comfortable and we would stay there again the bed was our favorite
clean and cozy as advertised
very clean and cozy
apartment was clean well stocked and comfortable
this place was clean and a great value
we enjoyed the homey clean atmosphere
thoughtful and attentive host
terri is a great host
a cozy user friendly apartment
she was very kind and very responsive
terri was a great host if we needed anything she was quick to respond
great location for mayo appointment
great location cute & cozy
great location close to the hospital
the location was great - a quick walk to mayo
easy walk to mayo
Read more reviews

8. Charming small-town guest house (from USD 58)

Perfect for four guests - a small family, friends, or just even a solo-traveler, this home in Rochester, Minnesota is quaint and welcoming. With cozy interiors, comfortable furniture, and tasteful décor, the home showcases the small-town charm of Rochester. With a fully functional kitchen, cozy rooms, and superb amenities like free WiFi and parking, guests will truly feel at home. It is also located near downtown, making it a great home base for those who want to explore the area. The home is also pet-friendly, so this is an added bonus if you want to enjoy your vacation with your furry friends.

Cascade Creek Guest House
Rochester, Minnesota, United States
386 reviews Superhost  Wifi Available
Entire guesthouse 2 Beds 4 Guests 1 Bedroom 1 Bathroom

Accommodates: 4

Top guest reviews
Amenities & Room:
the sofa bed is excellent
our stay exceeded our expectations the cottage is quiet cozy and comfortable - exactly as described
we had everything we needed for a comfortable stay and would definitely return
the place was comfortable and had everything i needed
very comfortable bed and excellent water pressure in the shower
very clean and convenient
clean and perfect cozy spot
clean comfy and in a quiet neighborhood
everything was clean and fresh :)
we enjoyed this clean cozy cottage
very friendly hosts and quick to respond
joshua was a great host
josh and kate are excellent hosts
very nice little place and great hosts
joshua and kate made us feel very welcome and were very responsive to our newbie airbnb questions
the location was perfect
easy location to get to mayo
great location close to the city center
great location easy to find
great location close to mayo and a nice walking/biking path
Read more reviews

9. Idyllic house near downtown (from USD 59)

This gorgeous and charming home is located ideally and is a great find for those looking to discover Rochester, Minnesota. With a classic interior that’s spacious and wonderfully accented, this home is a place you’d definitely feel welcome in. This two-bedroom, one-bathroom house easily sleeps up to six guests, making it a superb choice for families or big groups of friends. Access to amenities like WiFi, a well-equipped kitchen, a TV, as well as a washer and dryer are also provided. Guests can expect small but thoughtful touches like essential toiletries and a coffee maker as well as coffee to be available. You can also opt for street parking if you’re traveling with a vehicle.

5 blocks from Mayo, Adorable Upper Unit
Rochester, Minnesota, United States
414 reviews Superhost  Wifi Available
Entire home 2 Beds 5 Guests 2 Bedrooms 1 Bathroom

Accommodates: 5

Top guest reviews
Amenities & Room:
the furniture is very comfortable
a homey apartment with comfortable furnishings
i appreciated the extra bathroom amenities in case you forget to pack something
samantha’s place is comfortable and as described in the listing
perfect 2 bedroom apartment with a nice outdoor patio
cleanliness could be improved
clean and quaint upstairs apartment
the house was clean and cozy
clean and such a sweet place
the place was clean and pretty well kept
the hosts were excellent
thoughtful host flexible with our changing schedule
thank you for being such an outstanding host
samantha was also very responsive when answering our questions
very friendly quick responsive host
great location close to mayo
great location for our stay
great location if you are a patient at mayo cute little apartment
we also loved the location
cozy place with a good location and spacious bedrooms
Read more reviews

10. Modern and stylish duplex (from USD 62)

This newly refurbished home is modern, chic, and stylish. With up-to-date appliances, comfy fittings, and luxe furniture, the home is perfect for three guests. Centrally located, it is near restaurants, shops, and, of course, Mayo Clinic and St. Mary’s. It is also situated in a quiet neighborhood, ensuring a peaceful and restful stay. Guests also have full access to a welcoming living room and a full kitchen, so meals can be prepared if you don’t feel like dining out in the restaurants near the neighborhood. The home is also spotless and impeccably clean, so you’re sure to have fresh towels, and clean linens waiting for you after a long day in downtown Rochester.

Modern and fresh space very close to Mayo Clinic
292 reviews Superhost  Wifi Available
Entire townhouse 1 Bed 3 Guests 1 Bedroom 1 Bathroom

Accommodates: 3

Top guest reviews
Amenities & Room:
air conditioning worked very good
the bed and couch were comfortable
i love the roku tv & the keurig coffee dispenser
he had ceiling fans and air running at a comfortable 70 degrees when we arrived
quiet neighborhood very comfortable couch/love seat
clean and looks recently updated
very clean and stylish
clean an very comfortable
clean and well organized house
it was clean and nicely decorated
tom was a great host he answered all questions quickly
the host is responsive and professional
tom was very accommodating and pleasant
tom was very responsive
the owners are nearby and very personable and friendly
perfect location for mayo
great location and value
great location you can walk to mayo in about 20 minutes
close to everything and a great value
location was perfect as we were in close proximity to st mary’s hospital
Read more reviews

11. Welcoming suite for patients or students near Mayo

This beautiful and comfortable suite is very close to Mayo Clinic and is the perfect sanctuary for patients, relatives or students in the Clinic. The hosts will let you use their kitchen and laundry but they also provide a coffee and tea corner with some breakfast options. You will have all the bottom floor to yourself as well as your own private bathroom fully equipped with all the products you will ever need.

Be Our Guest-Welcoming Suite for All (near Mayo)
Rochester, Minnesota, United States
128 reviews
Private room in house 1 Bed 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
super comfy bed and couch; very relaxing
the bed was very comfortable and the ac welcome
the bed is comfortable the games appreciated and the space definitely met our expectations
the space was comfortable
it has a brand new private bath and the most comfortable bed imaginable
room is self contained clean and inviting
the space is very clean and comfortable
the room is very clean and private
space was exactly as described and immaculately clean
it was overall a clean and comfortable place to be
connor and renee are very nice hosts
renee and connor were very welcoming hosts
they were very welcoming and overall great hosts
connor and renee were wonderful hosts
connor and renee were wonderful hosts
located in a cute little downtown neighborhood and very close to the main downtown area
close to mayo nice quiet neighborhood
super comfy and a perfect location
very convenient location and they were very welcoming
quiet relaxing comfortable house in nice residential area close to city bike/running trails
Read more reviews

12. Larger house for a larger crowd

If you are a family or a bigger crowd seeking for something bigger, this conveniently located home will be the perfect choice for you. This cozy and beautifully decorated home has three bedrooms, a bathroom, and a fully equipped kitchen. There is also a neighborhood park with walking trails, perfect for your morning run or a relaxed picnic in the sun.

Blocks from St. Mary's and Mayo Clinic

13. Cozy one-bedroom with bathroom near Mayo Clinic

This cozy bedroom is located in a shared house very close to Mayo Clinic. You will be sharing the bathroom, the kitchen and all the other communal spaces with the rest of the tenant. The home is lovely and the location is really quiet and chill. Additionally, there is a beautiful porch where you can relax and have a glass of wine in the evenings.

Cozy one-bedroom with bathroom near Mayo Clinic

14. Cozy bungalow close to Mayo Clinic

Stay in one of the best best Airbnbs in Rochester. This lovely upstairs bungalow is located right in the center of Rochester and very close to Mayo Clinic. It is so central that you can walk almost everywhere you will probably have to be. The queen size bed is super soft and comfortable and it comes with luxurious linen and Aveda products for your showers. Your hosts will leave you a fully stocked kitchen full of goodies from the local bakery. Additionally, they might be willing to pick you up and drop you off at the airport.

The Urban Nest close to Mayo Clinic
Rochester, Minnesota, United States
137 reviews
Entire apartment 1 Bed 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
the bed linens and space were also very comfortable and stylish
the mattress bedding and living room seating were inviting and very comfy cozy
the apartment was just as pretty and tidy as it looks in the photos
the furnishings linens are impeccable this cozy apartment is well stocked with bath products bathrobes and delicious treats
the apartment exceeded our high expectations in comfort amenities charm and cleanliness
so clean and exactly as described
the apartment was very clean and nicely decorated
the space was clean quiet and comfortable
the apartment is sparkly clean and stylish
the apartment was exceptionally clean and obviously well cared for
the hosts communicate very easily
they are super hosts
dave and jolynn were wonderful hosts
jolynn is a wonderful host with a lovely apartment
jolynn was so kind and attentive to every detail
amazing place within walking distance to mayo
there is a lovely bike / walking trail close by
location is just a quick five minute walk to downtown and great restaurants/activities
the location is great as it is close to the mayo and st
the location is perfect for hospital visits
Read more reviews

15. Red cottage bungalow

This beautiful cottage bungalow is the perfect place to get close to nature nestled in 1.6 hectares (4 acres) on the Zumbro River. Although you will be in the middle of nature and really close to hiking and biking trails, the bungalow is only a 7-kilometer (4-mile) ride away from Mayo Clinic as well. To rest your tired feet, there is one bedroom with a queen size bed and two more single best in the common room. This is the perfect location for a speedy relaxing recovery or a peaceful retreat.

Rochester, Minnesota, United States
158 reviews Superhost  Wifi Available
Entire rental unit 3 Beds 4 Guests 1 Bedroom 1 Bathroom

Accommodates: 4

Top guest reviews
Amenities & Room:
a cozy well-equipped place the outdoor firepit is the best beautiful view
the cottage was very comfortable and well equipped with everything we needed for our stay
beds were very comfortable with ample blankets
outside we enjoyed our coffee at the little table set just in front of the sliding door
having a kitchen helped us save money and eat better for at least some of our meals
very clean and tastefully decorated
very clean quiet and comfortable
heidi's place is clean and peaceful
a very clean comfortable peaceful place to stay
extremely clean spacious nicely decorated and comfortable
lovely place and lovely hosts
she is kind and attentive
heidi is a gracious host and responds quickly to all questions and requests
kevin & heidi are kind helpful folk
our host heidi was very accommodating and even shared her freshly picked apples
quiet rural setting close to north end shopping with an easy drive to downtown
the location is perfect and beautiful
and a beautiful location right on the river
the house is in a great location close to everything
yet still close to the mayo restaurants shops and entertainment
Read more reviews

Explore Rochester

If you’re planning a trip to Rochester, consider staying in any of these amazing Airbnb vacation rentals. Although Rochester, Minnesota is a popular destination thanks to the renowned Mayo Clinic, there are so many things that you can do and lots of parks and attractions to enjoy during your stay. Explore this vibrant city soon!

Disclosure: Trip101 selects the listings in our articles independently. Some of the listings in this article contain affiliate links.

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Marilia Kaisar is a multidisciplinary storyteller from Greece. She identifies as a traveler, an artist, a writer, a journalist or an architect according to the circumstances. She is currently...Read more

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