10 Best HomeAway/Vrbo Vacation Rentals In Greenville, South Carolina - Updated 2021

homeaway greenville sc
Anne Marie
Anne Marie

You can’t help but fall in love with Greenville, South Carolina. The city is one of southern charm, but unexpectedly so. The downtown is not stately antebellum homes, but rather brick buildings which are separated by pedestrian-only streets and a rushing river. Greenville is one of America’s fastest growing cities, and with all, there is to see and do, and buy and taste, it’s hard to keep up. There are dozens of cultural attractions like galleries and museums of history and art. The city has over 100 eateries and 120 shops and boutiques to explore. It’s also a city where you can interact with nature, either by biking on the Swamp Rabbit Trail or traversing the bridge in Falls Park that overlooks the waterfalls on the Reedy River. Greenville is a spot you’ll want to explore on foot, which is why you should choose an accommodation right downtown. If you want to see all that the city has to offer, here are 10 of the best HomeAway vacation rentals in Greenville.

1. Historic apartment for a family (from USD 227)

You’ll be utterly charmed by this cozy yet chic apartment steps from Main Street. With its exposed brick, hardwood floors, and huge windows that brighten the rooms, it is a gorgeous space for a reasonable rate. The apartment has one bedroom and can sleep up to four people with the options of cots or the queen-sized sleeper sofa. Guests can enjoy conveniences like laundry in the apartment and a parking garage. The apartment is centrally located, so feel free to leave your car and explore the sights of Main Street on foot. You can also rent bikes and take them on the nearby Swamp Rabbit Trail.

1/2 Block From Main Street Downtown - PROFESSIONALLY CLEANED & SANITIZED
Greenville, SC, US
128 reviews
condo 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
the space is warm comfortable and convenient easy access through an adjoining garage
very clean and well equipped
wonderful property - great location very clean and well maintained
host was exceptionally responsive
owner was extremely helpful with every detail
the hosts really care about their guests and it shows
tricia was a great host and we had an awesome time
we had a fantastic experience with the host and the condo
wonderful condo in an excellent location in downtown greenville
the location is in a perfect place to explore downtown greenville
the location is close to the peace center and main street
easy walk to all of downtown
spectacular property and location that was perfect for our long weekend in greenville and clemson
Read more reviews

2. Penthouse with fascinating terrace (from USD 185)

Live the high life in this penthouse right in downtown Greenville! The rental is a spacious one-bedroom apartment with room for up to four guests. The best part is the outdoor terrace, which has cozy seating and lovely views of Greenville. It is the ideal spot to wake up with a morning coffee or have a glass of wine while watching the sunset. The rental is just a block from downtown, making this a convenient yet luxurious starting point for sightseeing.

Downtown Penthouse With Terrace, 1/2 block from Main St in the heart of downtown
Greenville, SC, US
105 reviews
condo 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
a beautiful apartment with a great outdoor terrace and terrific furnishings and accomodations
decorated with style yet super comfortable
very clean and well stocked
exceptionally clean updated and beautiful
the unit was very nicely appointed and clean
property owner very responsive
the owner was very easy to communicate with and the home was exactly as it was posted
great location to enjoy the town
easy walk to all the hot spots
we loved the location and walking to restaurants and shops of greenville
can’t beat the location and the place is so nice and well appointed
would definitely rent again great location clean & comfortable
Read more reviews

3. Charming apartment on a quiet street (from USD 96)

This quaint apartment oozes southern charm. You will feel right at home in the modestly yet tastefully decorated one-bedroom accommodation. Up to two guests can enjoy all the rental’s amenities, like a king-sized foam memory bed, laundry facilities, and secure wifi. The apartment is also pet-friendly so bring along your furry friends. If you will be staying in Greenville for an extended time, this would be a great option as the owner offers discounts on weekly and monthly stays. It is right next to the public library and art museum, so stay for a while and get to know the neighborhood.

Quaint Downtown Greenville Apartment on Quiet Street
Greenville, SC, US
81 reviews
Apartment 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
kitchen VERY comfortable bed comfortable living room with wifi
a nice comfy chair in the bedroom to sit and read along with that great bed would have made the bedroom
As I'm not much of a TV
I found the bed comfortable but those who require a firm bed might not agree
The home itself is fantastic Quiet and spacious
The apartment was clean well maintained and quite spacious (except for the bathroom)
The house had everything we needed and Michael was congenial and very helpful
The apartment is super clean and has all that you could need Large and clean eat-in
We were close to everything and really enjoyed our stay
I am giving a 5 star review with a couple of caveats
I can not say enough good things about Brooke and Michael
Ceiling lights do not provide a warm atmosphere
We had everything we needed and more Definitely planning to visit again
Reasonably quiet especially being so close to downtown
The property is 4 or 5 blocks from Main St with its stores and restaurants
It was very pleasant place to stay and easy walking distance to main street and downtown
and it's many delicious restaurants
This location was perfect for us as it was very close to downtown and easy to get to
Very roomy and well thought out amenities Walked to the main street several times Nice quiet street Would definitely stay again
Read more reviews

4. Spacious and colorful house for a large group (from USD 850)

If you’re in need of a rental that can accommodate a large group of people, this home is for you. It has 6 bedrooms and can host up to 16 guests, ideal for families traveling together or a reunion of friends. The interior of the house is colorful and friendly, a perfect spot for kids or the young at heart. Each room has its own sink, TV, and Keurig maker, so no one will ever have to crowd the kitchen or bathrooms. The rental also comes with access to bike rentals to take on the Swamp Rabbit Trail. There are lots of other sights in walking distance, like Falls Park and the Pendleton Arts District.

Vacation Rental House in Downtown Greenville SC With 6 Bedrooms, Sleeps 16
Greenville, SC, US
26 reviews
House 6 Bedrooms 4 Bathrooms
Top guest reviews
Amenities & Room:
The 6 bedrooms accommodated everyone and the kitchen
dining living space is large enough for all of us to be in the space together
The kitchen was graciously stocked with everything one would need and even more
My only complaint would be the web cam that is inside the house looking over the living room and kitchen
was right at our fingertips With a fully stocked fridge and plenty of coffee
The house and kitchen were clean inviting and ready for entertainment and dining Everything for a wonderful breakfast
it was clean and very accommodating
The "Indie Craft Parade" was definitely a highlight for our group
She really came through for us
With Wendy's help guidance and flexibility we rented the entire Inn for our long weekend
We arrived early and were allowed an early check-in
Wendy's service and care was exemplary and she helped make our weekend more than memorable
so the house is presented by a host who is clearly generous of heart and who has successfully created a very enjoyable atmosphere
Great property in a great location
That seems to go a little too far
Within walking distance of grocery store restaurants
We loved the location so close to Falls Park
It was a short walk to downtown and a $5 Uber ride when we didn't want to walk Perfect weekend
Read more reviews

5. Cozy suite in a stylish, historic home (from USD 126)

This suite is located in a charming home that dates back to the 1920s. The interior has been fully renovated, and the owners used materials from the original building to give it an authentic historic vibe. The downstairs suite can accommodate up to six guests in two bedrooms. If you’re looking for a rental that can host more people, the suite upstairs can also be rented out if it’s available. This rental is within walking distance to Fluor Field, where the Greenville Drive baseball team plays, as well as Falls Park, the heart of downtown Greenville.

Stylish Downtown House near Fluor Field Suite A
Greenville, SC, US
56 reviews
House 2 Bedrooms 2 Bathrooms
Top guest reviews
Amenities & Room:
while in Greenville Very comfy master bed super cozy room for our girls with two single beds
but they provide coffee and have plenty of counter space and a large fridge for your food
The kitchen is not only beautiful
The condo was very spacious
Also the TV was a bit of a disappointment My father likes to watch local news in the evenings and this was only internet TV which was new to us
The bedrooms are comfortable clean and also beautifully decorated
and we really appreciate the coffee
Property is updated and beautifully decorated
The place is clean spacious beautifully decorated comfortable and in a fantastic location very close to downtown
short Uber ride to everything Very well decorated with everything you need
stay and the owner was super easy to work with
one of the owners is very responsive straight forward and pleasant to work with
and we fell in love with the condo
The owners were very responsive and the home was beautiful
We spent two hours the first night trying to make it work
The location is just off of Main Street and very convenient
Stayed here for one night while in town to go to a play at The Peace Center Great location within walking distance or
We pick a different city to explore every November
The house is within walking distance to plenty in downtown Greenville Highly recommended
The location of the property is perfect for riding bikes or heading out for a great meal
Read more reviews

6. Condo on Earl Street district (from USD 76)

Enjoy the perks of a hotel with the independence and affordability of a vacation rental at this convenient accommodation. The apartment is located on historic Earl Street, one of the most beautiful streets in a lovely part of downtown. It has two bedrooms and can sleep up to five guests. Amenities include complimentary breakfast, concierge service, and laundry facilities. Parking is included for both cars and bikes, and pets are welcome with advance notice.

Downtown Greenville Historic District Vacation/Corporate Condo!
Greenville, SC, US
40 reviews
condo 2 Bedrooms 1 Bathroom
Top guest reviews
Amenities & Room:
the tv and internet were great and the furnishings fine
nice little apartment- perfect for a visit to greenville
there were definitely moments we wanted an extra bathroom
great space with lots of room in the master bedroom
loved the historical neighborhood the apartment was in
condo was very clean& safe
your condo was clean and comfortable for a short or long term stay
a very clean and comfortable condo my husband and i enjoyed staying there
it was well stocked and clean
it was well stocked and super clean
easy process and communicative owner is alway nice
this condo is in a great location
ann's condo is on a nice quiet street within walking distance of downtown
nice place great location and perfect owner
it’s a nice neighborhood for evening walks where everyone says hi
in fact it was probably the best stocked place i've ever stayed in
Read more reviews

7. Stunning home with unique character (from USD 165)

This studio has a unique atmosphere and design you won’t find anywhere else. The exposed brick walls, wooden ceiling beams, and chandelier create a warm atmosphere. Touches like the weathered bathroom sink and freestanding French doors separating the bed from the living area give the place an antique feel. It is sized for up to four people and is spacious enough that it won’t feel cramped. There is a large balcony outside with a bistro table for dining al fresco. If you’re visiting in the summer months, visit the farmer’s market on Saturday mornings and bring back coffee, pastries, and other goodies!

Downtown Greenville with Large Private Balcony
Greenville, SC, US
87 reviews
condo 0 Bedrooms 2 Bathrooms
Top guest reviews
Amenities & Room:
that you are free to use
It really makes you feel like home
Very much to our liking
Such a cool place Comfy bed and great amenities
Once you park you do not have to get in your car again until you leave
Location can't be beat close to everything
The Nest is not your "cookie cutter" condo rental
still private and super quiet Wonderfully decorated Would definitely recommend
She always answered all questions promptly and was extremely nice
Owner was great to work with If this spot is available do not hesitate to book
Great location with Debbie as our great host
I already have family looking to book in the future
The owner leaves soap paper towels foodstuffs
The location is amazing walking distance to so many restaurants yet
The location was awesome about a 2 minute walk to Reedy River and just steps into downtown shops and restaurants
The location is less than a block from Main Street and excellent walkability
Everything is in walking distance
but it is still very quiet
Read more reviews

8. Trendy condo in a great location (from USD 251)

You can’t beat the location of this condo rental. It is right by Main Street and is within walking distance to many Greenville sights. You’ll be right across from The Peace Center for a concert and other cultural events. There is also a free trolley that will take you to all the other attractions, like the Children’s Museum or historical museum. The apartment has two bedrooms for up to four guests. It is spread across two floors and has lots of living space so you won’t feel crowded.

Condo in The Center of Downtown (includes parking spot!)
Greenville, SC, US
40 reviews
condo 2 Bedrooms 2 Bathrooms
Top guest reviews
Amenities & Room:
The condo is very spacious and comfortable
Comfy beds nice towels and toiletries
We were treated to a crawling bug in the master bed room on first night
3rd floor bedroom is private with hardwood floors
(couple Uber rides too)
The bedrooms and baths were very nicely appointed
old and new We had everything we needed and the location couldn't be beat
She was quick to answer any questions
The host was very accommodating and helpful
gracious and went out of her way to make us feel welcome
the brick wall and exposed beams
We arrived a little early and all was ready for us Music playing lights on snacks coffee
It is a 2 minute walk to restaurants and shops
Just steps away from Main Street 14 minute walk to Bon Secours Wellness Area and 4 minute
The location could not be better Half a block off
The location is fabulous if you want to walk to all the shops parks and restaurants
walk to the beautiful Falls Park
Read more reviews

9. Cozy apartment for a steal (from USD 70)

There is nothing wrong with seeking out the most affordable accommodation you can find while traveling. If a cheap nightly rate is your main criteria, check out this cozy one-bedroom apartment. Not only is it affordable, leaving room in your budget for all the attractions in Greenville, it’s also just as charming as any other rental on this list! Up to two people can stay in the apartment, which is bright with minimalistic decor. It has a private entrance, a spacious kitchen, and a living room with Netflix and local TV channels. The rental also has its own courtyard with a table and chairs, where you can sit and take in the friendly surrounding.

Great Deal on Downtown Greenville Apartment
Greenville, SC, US
36 reviews
Apartment 1 Bedroom 1 Bathroom

10. Historic charmer with modern amenities (from USD 171)

You’ll feel like you’ve been transported back in time in this lovely apartment. It is located in a historic building and elements of the antique structure are still visible, like the tall ceilings that let in lots of light. The decor echoes the past as well, with plush parlor chairs, rich wooden furniture, and historic paintings throughout the home. There is one bedroom, and a total of six sleeping spots for guests with a pull-out sofa in the living room, and two sleeping cots available. Though the apartment is close to the busy downtown streets, it is on a quiet block where you can relax and feel at home.

Historic Charmer 3 blocks from Main St!!! PROFESSIONALLY CLEANED AND SANITIZED
Greenville, SC, US
45 reviews
condo 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
(shared room toddler in pack
The bed was comfy even the pull-out
n play)-kitchen could use a few more items
(For us due to toddler & long stay)-unloading/loading (lots of stuff for toddler)-bed/pillows not super comfy & bed squeaked a lot when turning over/getting in/out of bed
Very comfortable and well appointed place
very clean and nicely decorated
The apartment was very clean
So clean - sweetly decorated - homey AND best location
It was absolutely adorable and the court yard was also beautiful and very quiet
and she was very friendly and helpful
The owner is very responsive as well
The host reached out to us before our stay and we knew we could contact her if we needed anything
We had a wonderful visit and enjoyed the Fall for Greenville festival which we walked to and the zoo
close to all that Greenville has to offer Communication from the owner is excellent
but not a big deal
It is just a few blocks from Main Street and very cute and comfortable Also close to Publix grocery store and many restaurants
very charming historic building restored nicely Downtown Greenville is a quick walk away and
Love the location walking distance to everything downtown
Beautiful home in a historic building within walking distance of downtown and the arena
Read more reviews

Discover why downtown Greenville is one of the best in the country

Greenville is often said to have one of the best downtown neighborhoods in America. It is friendly and welcoming, with pedestrian walkways designed to let you explore on foot. There is a free trolley around the city that will take you to all the cultural attractions there are to see. Falls Park is the heart of the city and often hosts festivals, concerts, and outdoor movies and plays that bring the community together. It’s no wonder that Greenville is getting so much attention, so book your vacation rental and start planning your own visit today.

Disclosure: Trip101 selects the listings in our articles independently. Some of the listings in this article contain affiliate links.

Get Trip101 in your inbox

Unsubscribe in one click. See our privacy policy for more information on how we use your data

Anne-Marie works in publishing by day and aspires to travel as much as she can. While she has not yet seen the whole world, she's eager to learn and write about it!

 Want to contribute as a Local Expert?
Explore Greenville
Good things are meant to be shared!