Mississippi is a fascinating place to visit for staunch adventurers and nature lovers. Gulf Islands National Seashore, which boasts beautiful beaches, rich coastal marshes, and historic forts, is partially located along this state. It is also a great place for picnicking, hiking, and camping. Meanwhile, Mississippi’s Grenada Lake offers the ultimate fishing and watersports experience. Laidback travelers can try Mississippi’s mouth-watering food or visit its museums. What’s more, everyone can take their vacation to the next level by booking an accommodation that offers spa services and soothing amenities that you can come home to after spending the day outdoors. Keep reading to learn more about the best spa resorts in Mississippi, USA.
We handpicked these listings carefully, considering (wherever possible) recent guest reviews, location, accommodation type, prices, availability of dates, decor, and access to spa and wellness services. The image galleries get refreshed with the latest updates regularly. They were last updated on October 28, 2025.
1. Harrah's Gulf Coast; Biloxi (from USD 87)
Forget about your worries at this beautiful property in Biloxi. In addition to its elegantly designed rooms with convenient amenities, Harrah’s Gulf Coast features Bellissimo Spa & Salon. Check the spa menu for the age requirement to enjoy its services. Guests over 18 can request different massages and body treatments. Moreover, guests can also use the equipment at the 24-hour fitness center inside this spa for free. Meanwhile, guests of all ages can get a facial, a haircut, a manicure, or a pedicure.
In addition, this accommodation also has a pool overlooking the Gulf of Mexico.
Harrah's Gulf Coast, A Caesars Destination
Address: 280 Beach Boulevard
2.11 km (1.4 mi) from Hard Rock Hotel & Casino Biloxi
2. Palace Casino Resort; Biloxi (from USD 106)
This upscale property allows you to enjoy your holiday in style. It features cozy rooms, some of which have a whirlpool tub. Once here, pamper yourself at the on-site Pure The Palace Spa open every Thursday to Monday from 9am to 7pm. Here, you can avail of facials, massages, and skin and body treatments. Moreover, it also has a dry sauna and steam room.
Remember to call for an appointment and check their special packages, including the First Time Spa Visitors Special and Monday Locals Special.
Palace Casino Resort
Address: 158 Howard Ave
2.64 km (1.7 mi) from Hard Rock Hotel & Casino Biloxi
3. Golden Nugget Biloxi; Biloxi (from USD 110)
This paradise in Biloxi offers spa suites that put guests close to the fitness facility and infinity pool, perfect for those who want easy access. Moreover, you can indulge in a massage, a body wrap, or a rejuvenating treatment at the on-site Spa & Salon open from 9am to 5pm from Thursday to Sunday and from 9am to 6pm on Saturday.
In addition, this property also has a sauna, a steam room, and a whirlpool. Check out the special packages and salon pricing if you have a Mississippi driver’s license.
Golden Nugget Biloxi
Address: 151 Beach Boulevard
2.61 km (1.7 mi) from Hard Rock Hotel & Casino Biloxi
4. IP Casino Resort Spa - Biloxi; Biloxi (from USD 107)
IP Casino Resort Spa - Biloxi boasts premium and deluxe accommodations. Go on a refreshing swim, lounge in the cabanas, or grab your favorite cocktails by the poolside bar. Moreover, there are seven on-site eateries, so you will never run out of options.
End your day with a relaxing massage or a body and beauty treatment at the on-site spa, Senses Spa & Salon. In addition, manicures and pedicures are also offered here. Note that you’ll need to make an appointment to avail yourself of the spa services. Also, guests over 18 years can take a day pass for 50 USD per person.
IP Casino Resort Spa - Biloxi
Address: 850 Bayview Ave
2.16 km (1.4 mi) from Hard Rock Hotel & Casino Biloxi
5. Beau Rivage; Biloxi (from USD 167)
This highly acclaimed resort in Biloxi is the ideal getaway spot. You can lounge around or swim in the pool on the second-floor deck. In addition, it’s home to Spa & Salon, which is open daily from 9am to 6pm. Be sure to check the age requirements if you wish to avail of its services. It offers body wraps, facials, massages, and hair and nail services. Moreover, the spa also has a whirlpool and a sauna.
Beau Rivage
Address: 875 Beach Blvd
360 meters (0.3 ft) from Hard Rock Hotel & Casino Biloxi
6. Gold Strike Casino Resort; Tunica Resorts (from USD 124)
Rejuvenate your body and clear your mind at this top-notch resort in Tunica Resorts. This property has rooms that offer views of the Mississippi River. Additionally, it features Stay Well rooms with the latest technologies to promote wellness.
The on-site spa, open from Thursday to Sunday from 9am to 5pm, offers different massages and treatments, and you can avail of aromatherapy, warm stones, and custom exfoliation. In addition, be sure to check out the different on-site dining options available here.
Gold Strike Casino Resort
Address: 1010 Casino Center Dr
513.34 km (319.0 mi) from Hard Rock Hotel & Casino Biloxi
7. Harlow's Casino Resort & Spa; Greenville (from USD 127)
This resort boasts an on-site spa, The Magnolia Day Spa, open from Monday to Saturday from 10am to 7pm. It offers a variety of massages, facials, nail treatments, and hair removal services and also features special packages.
You can choose from various massage therapies, such as Deep Tissue and Bamboo Fusion Massage. Try the special skin care treatments, which start from 115 USD for a 50-minute session.
You can make your vacation memorable by booking a room with a hot tub. Moreover, the seasonal pool is also perfect for soaking up the sun or swimming, while the fully equipped fitness center will help you stay active.
Harlow's Casino Resort & Spa
Address: 4280 Harlow's Blvd
387.08 km (240.6 mi) from Hard Rock Hotel & Casino Biloxi
8. Hard Rock Hotel & Casino Biloxi; Biloxi (from USD 108)
This resort offers a luxurious and unique getaway. It has two towers offering stunning views of the city, the pool, and the Gulf of Mexico. What’s more, enjoy a rejuvenating and cleansing experience at Rock Spa open on Wednesday to Monday from 9am to 5pm. Aside from massages and facials, this spa offers manicures, pedicures, and wraps.
While you’re here, be sure to take advantage of the pool and cabanas. Moreover, you can use the sauna, whirlpool, and steam room in the on-site fitness center, Body Rock.
Hard Rock Hotel & Casino Biloxi
Address: 777 Beach Boulevard
50 meters (163.0 ft) from Hard Rock Hotel & Casino Biloxi
9. Hollywood Casino Gulf Coast; Bay St. Louis (from USD 107)
Feel the relaxing ambiance at this luxurious property that offers waterfront accommodations. This hotel boasts impressive amenities, such as an outdoor pool, spa tub, and 24-hour gym. Want to have your nails done or treat yourself to a facial? Call for an appointment at Azalea Spa & Salon. The on-site spa offers various spa services and discounts, so don’t forget to check the menu and special offers.
Hollywood Casino Gulf Coast
Address: 711 Hollywood Blvd
45.16 km (28.1 mi) from Hard Rock Hotel & Casino Biloxi
Luxuriate and relax in style
Take a break and pamper yourself with a rejuvenating spa experience. Check out this list for the best accommodations in Mississippi that allow you to luxuriate and relax in style.
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