Rochester, the third-largest city in Minnesota and famous as the home base of Mayo Clinic, offers more than an excellent place to live in. Renowned for its sophisticated lifestyle overflowing with congeniality, modernization, and compassionate values, the city also boasts a scenic natural landscape with a relaxing urban vibe filled with shopping, amusement, and dining options. Take the Mayowood Mansion trolley tour and learn the history of Mayo Clinic. Discover the city’s hiking and biking trails that span for more than 85 miles (136.8 kilometers). End the day watching a concert in one of the newly renovated events and convention centers or have a sumptuous meal at one of the lively diners in the city. Book the best Vrbo vacation rentals in Rochester for a luxurious stay in a city that promotes health and wellness. Check our list below!
We handpicked these listings carefully, considering (wherever possible) Superhost status, recent guest reviews, location, accommodation type, prices, availability of dates, decor, and amenities. The image galleries get refreshed with the latest updates regularly. They were last updated on October 24, 2025.
1. Gorgeous bungalow in a cul-de-sac (from USD 192)
This gorgeous home has all-white walls, big bay windows, and chic modern furniture. The main floor has garage access and the main entrance opens to a cozy living room with a fireplace. The kitchen has marble-topped counters and an island. Dine in the furnished sunroom with awesome garden views seen through the floor-to-ceiling windows. Three large bedrooms that are cozy for six guests with two private bathrooms are distributed on two floors. The lower level also features a lounge with cable TV and an electric fireplace, a tiny office, and the utility room with laundry facilities. The well-kept garden has a fire-pit where guests can gather around to keep warm. The dwelling is in a cul-de-sac near shops, restaurants, St. Mary’s hospital, and downtown.
Rochester, Minnesota, United States
Top guest reviews
Host:
the hosts were excellent - very responsive and provided good information in advance throughout the processshelly and shawn were excellent and very responsiveshawn and shelley were easy to communicate with and very responsive to anything we neededthe water bottles and chocolate they provided were also kind gesturesshawn and shelley were easy to work with and very responsive to our needsLocation:
the location is perfect toogreat location in you need to be at the mayo clinicit is a beautiful home in a safe quiet neighborhood near trails and grocery storeCleanliness:
kathy house is very clean and comfortablethis house was very clean and organizedit is clean cozy quiet and will stay her againvery clean modern and close to the hospital and clinicthis was my second stay and the house was just as fresh and clean as the first timeRead more reviewsAmenities & Room:
beds are great and house is warm if visiting in winter and not used to the cold
2. Sleek multi-level home near Bear Creek (from USD 116)
Enjoy picturesque views of Bear Creek and Slatterly Park in front of this multi-level home. Its sleek modern design is spacious enough to host 10 guests. The main level features the fully equipped kitchen and living room surrounded by huge picture windows. Have great outdoor views while watching TV or sitting by the fireplace in the living room or while cooking in the kitchen. The upper level contains the full bathroom and the three bedrooms with king and queen beds. The lower level has the two other bedrooms with a queen bed and sleeper sofas, another bathroom, the laundry area, and the family room. The house is surrounded by a well-manicured garden with a patio and porch ideal for barbecues and outdoor fun. There’s a two-car parking garage behind the main house.
1103 8 1/2 Street SETop guest reviews
Host:
owners are very friendly and helpfulthe owners are very hands-on and graciousfinally the owners are very nice and extremely helpfulLocation:
wonderful house great location fair pricethe neighborhood is quiet and the park across the street was perfect for the kidswe loved the house and it was very close to mayo clinicnice quiet friendly neighborhood and right across from a park with a creekthe park across the street was an added bonus for walking and decompressing in the eveningsCleanliness:
it was beautifully appointed and extremely cleanthe house was very clean kitchen well stocked and everything we needed was available including good towelsgreat location comfortable clean and updatedRead more reviewsAmenities & Room:
a more comfortable "standard" office chair would be in improvement thoughit was great a sleeping 10 and had two separate tv/hangout spaces and nice kitchen appliancesthe kitchen was nice with stainless appliances and a small table for four to eat atthe lower level wet bar area had a larger table that was great for gamingit was beautiful and comfortable with more space than it looks from the outside
3. Amazing house for seven guests (from USD 100)
This fully furnished Aster House is in a quaint neighborhood not far from Rochester downtown, St. Mary’s Hospital, and Mayo Clinic. It’s great for a four-night stay for seven guests with kids and pets. This warm and cozy house has soft beige interiors and light hardwood flooring. Sink into the soft leather sofas while watching Roku, Netflix, and cable TV in the living room. The American-style kitchen has a dining table set for four. The main bedroom is on the first floor while the other three bedrooms are on the second. The rooms are air-conditioned and equipped with internet and thick cushioned queen and twin beds. There are one-and-a-half bathrooms. The garage and laundry facilities are in a separate building.
Rochester, MN, US
4. Luxurious home near a golf course
This elegant and sparkly clean six-bedroom and six-bathroom home is on a private estate near Mayo Clinic and Rochester Country Club. It hosts large parties up to 12 guests. The main floor has a gourmet kitchen, a casual and formal dining area, two living rooms, and the cozy den. Two private bedrooms and a bar that opens to the pool area is located on the lower floor. The other three bedrooms and bathrooms are on the second floor. Dine in the screened-in patio beside the kitchen overlooking the manicured garden, heated pool, and wide deck. A gorgeous view of the country club and golf course is seen behind the house. Though a minimum five-night stay is required, long-term stays are allowed.
Accommodates: 12
Minimum Nights: 1
Refund Policy : 100% refund if you cancel at least 60 days before check-in.
Top guest reviews
Host:
owner was very helpfulRead more reviewsAmenities & Room:
we would have liked to have more tvs in the house but overall great propertybeds were very comfortable
5. Unique storybook house near St. Mary’s
Now is your chance to live in a Fairy Tale like home for at least one night! It has a Hamlet-style exterior design with modern interiors and furnishings. The three spacious bedrooms sleep six guests with its king- and queen-sized beds. The full-sized couch in the living room can sleep an extra guest. There’s a fully equipped kitchen, dining area, and a basement laundry area. The loft-style bedroom has a game room where guests can play billiards, surf the net, or watch cable TV or DVDs. You can smoke and cook barbecues in the yard. The house is two blocks to the grocery, a mall, and diners.
Accommodates: 6
Minimum Nights: 1
Refund Policy : 100% refund if you cancel at least 14 days before check-in.
Top guest reviews
Host:
host was responsive everything went smoothlyhost was very helpful and kindowner was excellent to deal withthe hosts are very sweet and accommodatingvery responsive to my questionsLocation:
we chose to stay here again because of the great location to stsuper convenient location to the clinic and fresh thyme market was also only 2 blocks awayit has been wonderful to be able to stay so close to our daughter and the hospitaleasy walk but already a little chillythe location is awesome in relation to mayo clinic and everything you need is within a 5 minCleanliness:
cleanliness is a must for me and this did not disappointvery clean and comfortable while i was having a procedure done at stclean and organized close to mayo jessica was a gem and very attentiveRead more reviewsAmenities & Room:
so nice to have a complete kitchenthe house is very comfortable and has everything one would need for any length of stay
6. Elegant two-bedroom basement apartment
The rental is in a quaint neighborhood near Mayo Clinic and Rochester center. The lavish apartment has a black and white interior motif, hardwood flooring, and impressive chic furniture. The open plan is shared by a modern kitchen with marble counters and an island; an elegant dining table that seats six; and a cozy living room with thick cushioned sofas. Two spacious air-conditioned bedrooms on the same floor are perfect for a family of four with kids. The host provides free linens, cable TV, free internet, laundry facilities, on-site parking, and heating. Housekeeping services are optional. The owners live above the apartment, but guests have their own private back entrance. Guests may share the use of the patio and garden with the owners.
Accommodates: 4
Minimum Nights: 2
Refund Policy : 100% refund if you cancel at least 30 days before check-in.
Top guest reviews
Host:
owner was easy to work withwas very impressed with the decorating skills of our hosta nice home away from home with wonderful emenities and a most responsive and generous ownervery helpful and thoughtful ownerLocation:
we'll definitely check this location first for our return tripsthe location was perfect so close to the location of the tournament and many restaurants and coffee shopsnice place not a far drive from mayo clinicbeautifully decorated and appointed; easy to get to; quiet areaa good place to restCleanliness:
the apartment was very cleanRead more reviewsAmenities & Room:
two beautiful bedrooms and most of a kitchen so a small family would do finewe would definitely stay again kitchen well-equipped with most of iytvhhnice set-up and very comfortable beds and linensbeds were the most comfortable we had ever slept inthe beds and linens were amazing
Relaxing Rochester rentals
Whether you are in town for a tournament or treatment, you’ll find these elegant rentals suitable for your impeccable taste. It has all the modern amenities you need and the perfect location with its close proximity to Mayo Clinic, golf courses, creek, and parks. No wonder you feel so relaxed when you’re in Rochester! Remember to book these vacation rentals when making travel plans to Michigan.
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