5 Best Vrbo Vacation Rentals In San Diego's Mission Hills, California

Louise
Louise 
Updated
| 5 min read

Located on the hilly part near downtown San Diego and south of the San Diego River, Mission Hills is an affluent and upscale neighborhood with luxurious vibes and high-end lifestyle. From this location, you can see the majestic view of the San Diego Bay and Old Town San Diego. Though mostly residential, when you head over the Washington Blvd, you’ll find a plethora of expensive and exquisite restaurants, luxurious retail stores, salons, movie theatres, and other well-visited establishments and attractions. If you are planning a quick getaway to this wonderful neighborhood anytime soon, here is a list of the best Vrbo accommodations in San Diego’s Mission Hills, California that you can choose from. Feel free to browse below.

We handpicked these listings carefully, considering (wherever possible) Superhost status, recent guest reviews, location, accommodation type, prices, availability of dates, decor, and amenities. The image galleries get refreshed with the latest updates regularly. They were last updated on March 13, 2023.

1. Newly renovated, charming vacation rental (from USD 275)

If you are longing for some peace and quiet time away from the hustle and bustle of downtown San Diego, this vacation rental is ideal for you. It is a charming fully furnished home with bright interiors and lovely hardwood flooring. It has two cozy and relaxing bedrooms, two private bathrooms, a large modern kitchen with upscale appliances, a lovely dining area, a comfy living room with a flat-screen TV, a fireplace, and expansive windows that allow lots of natural light to come in, and an outdoor sitting area.

Stayed at this property?
71 reviews   Wifi Available
House 5 Guests 2 Bedrooms 2 Bathrooms

Accommodates: 5
Minimum Nights: 2
Refund Policy : 100% refund if you cancel at least 30 days before check-in.

Top guest reviews
Amenities & Room:
walked to the farm-to-table restaurant
cooked many meals in the enormous kitchen
The beds were comfortable and everything was spotless
It has a large kitchen area where we spent lots of time cooking conversing and hanging out The dining and living room areas are cozy
spacious and very comfortable The bedrooms and bath area make you feel right at home
Cleanliness:
The house is immaculately clean and is just as pictured
Host:
Belinda and her husband are amazing hosts
Melinda was incredibly quick to respond to any questions we had about the house and made sure she introduced herself and welcomed us to her rental and the neighborhood
House is completely renovated with upscale appliances
However I would like to give the owners the kudos they deserve
When we wanted to explore the zoo SeaWorld Balboa Park and the beach Hwy 5 was easily accessible
Location:
The house is located in a quiet neighborhood and walking distance from wine bar and very cool coffee shop
We enjoyed a relaxing dinner in the secluded backyard garden that has a charcoal grill
It's in a wonderful neighborhood
The neighborhood is quiet and close to restaurants and highway access but a GPS is really handy in the Mission Hills area especially at night
We enjoyed the wonderful ocean breeze on the porch and 2 patios walked to a local coffee shop and visited wonderful restaurants nearby
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2. Stunning and modern vacation house with panoramic views for 12 guests (from USD 816)

Showcasing a majestic view of the San Diego Bay and downtown, this stunning modern accommodation is an interior design wonder. Featuring bright furnishings and a cool and airy ambiance that is homey in nature, this vacation rental will give you the maximum convenience and coziness that you will love. Plus, it is spacious and comfortable enough for up to 12 guests. It has three stylish and chic bedrooms, three gorgeous private bathrooms, a modern kitchen, a lovely dining space with a picturesque view of the area, a relaxing living room area with lots of natural light, a flat-screen TV and a fireplace, a fabulous outdoor table setting, two balconies, a garage, and a backyard grass area.

Stayed at this property?
26 reviews   Wifi Available
House 12 Guests 4 Bedrooms 4 Bathrooms

Accommodates: 12
Minimum Nights: 4
Refund Policy : 100% refund if you cancel at least 30 days before check-in.

Top guest reviews
Amenities & Room:
We put 2 in the master king bed 1 in the other 3 beds and 1 on the couch in the living room
You can definitely sleep another 2 comfortably on couches and double-up in beds if needed
The house itself is amazing - nice views very spacious cozy and comfortable
The house has floor to ceiling windows which is great for the view but traps all of the heat
You'll have everything you need when staying here
Cleanliness:
You also can't beat the location
The house was large and homey
We were 6 guys and there were 4 beds
Host:
The host was awesome - very responsive and accommodating
Scott was a perfect host Checked on us and offered all the help we needed even on a not so typical hot Friday in San Diego
Very responsive to anything we needed
Overall the home worked out for us but potential renters should know
Easy commute to gaslamp district for work
Location:
Surrounded by a cool neighborhood with restaurants stores and easy freeway access
This house did not live up to the property description
he suggested the sofas but clarified the sofas are not sleeper sofas
- we seemed to be within 10-15 minutes of everything we needed to do - beach bars
The home is large with lots of space and a very lovely patio to sit out and enjoy wine and views of the city especially at night
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3. Lovely accommodation rental near Old Town San Diego (from USD 195)

This charming vacation rental with a parking space is located near Old Town San Diego. It is ideal for families as it can accommodate up to six guests. It is fully furnished, cozy, and has delightful amenities that you will love. Plus, it has a relaxing home-away-from-home kind of vibe. In total, it features two comfortable bedrooms, two private bathrooms, a kitchen equipped with cooking essentials, a lovely dining space, a cozy living room, and a garage, To top it all off, it is located within a short distance from San Diego’s top tourist attractions.

Stayed at this property?
5 reviews  
townhome 6 Guests 2 Bedrooms 2 Bathrooms

Accommodates: 6
Minimum Nights: 2
Refund Policy : 100% refund if you cancel at least 14 days before check-in.

Top guest reviews
Amenities & Room:
Kitchen was a good size Small dining table fit 2 people Located between Little Italy and Old Town (but probably closer to Old Town)
The only negative was the AC wasn't working
Host:
so it really wasn't missed Owner was always within reach if we needed him
We enjoy walking and we easily walked every where and when needed we used both Uber and the metro
Primarily came to visit colleges with our eighteen year old son Comfortable place to stay easily fit a family of four with older children Nice having two bedrooms and two bathrooms
It has been renovated out front and looks very nice
Location:
Property was well kept and centrally located Walking distance to Old Town and minutes from Sea World
It is close to Old Town and a short distance from Little Italy
The photo on Google Earth does not represent how this property now looks
Great place to stay Kitchen and bathrooms are very well done and we enjoyed the view from the balcony Loved that it was kid friendly as well Thanks for a great stay
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4. Restful hideaway with a view of Wooden Canyon and Bay (from USD 417)

Boasting of majestic Wooden Canyon and Bay views, this charming vacation rental is the perfect haven to spend your weekend getaway in Mission Hills. It stands in a quiet and peaceful neighborhood with lots of fresh air and relaxing views. It is tastefully furnished with well-curated displays and has a homey ambiance. It is modern with lovely hardwood flooring and rustic accent. It houses three comfortable bedrooms, two private bathrooms, a spacious and functional kitchen, a lovely dining area, a cozy living room with a flat-screen TV and a fireplace, and a terrace with a table setting.

Stayed at this property?
140 reviews   Wifi Available
House 6 Guests 3 Bedrooms 2 Bathrooms

Accommodates: 6
Minimum Nights: 4
Refund Policy : 100% refund if you cancel at least 30 days before check-in.

Top guest reviews
Amenities & Room:
like fresh flowers and delicious homemade coffee cake
There were shows and is was a little cooler outside
The home was exactly as described
Cleanliness:
The house is especially clean
Host:
She even purchased a new set of beach toys for our daughter
Historic remodeled home with quality finishes
The owner was very helpful and pleasant
Susan was great- gave us some GREAT suggestions of places to eat Very happy
so any questions are answered on the spot and you can contact with any additional questions Everything we needed was taken care of
Location:
There are restaurants and grocery markets and a park all within 10 minutes walk
This is probably one of my favorite stays in the Old Town San Diego area perfect convenience location and walking distance to restaurants on
The location is excellent with walking distance to town
Wonderful house Beautiful area and the location was perfect
Everything one needs for a peaceful vacation
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5. Tuscan estate with panoramic views (from USD 899)

Showcasing a gorgeous Tuscan-inspired Home with authentic European vibes, this vacation rental boasts not only of an architectural wonder estate but also of the breathtaking panoramic views of the area. If you are looking for a place to spend your weekend getaway with your large group of family or friends, this rental can house up to 14 guests. It is luxurious, sophisticated, and has wonderful amenities. It houses five charming bedrooms, four fabulous private bathrooms, a modern kitchen, a lovely dining space, a relaxing living room with comfy couch seats, a flat-screen TV, a fireplace, and expansive windows and doors that open to a majestic view, a breathtaking pool, and a terrace with a seating area.

Stayed at this property?
129 reviews   Wifi Available
estate 14 Guests 5 Bedrooms 4 Bathrooms

Accommodates: 14
Minimum Nights: 3
Refund Policy : 100% refund if you cancel at least 60 days before check-in.

Top guest reviews
Amenities & Room:
The beds were very comfortable
(I thought it looked amazing in the photos myself
There was more then adequate space for everyone to stretch out
a cold shower just had to work in one bathroom as they were not able to fix it
the planes take-off and land
Cleanliness:
The house was so spacious and clean
The house was supplied with beach towels
Very updated comfortable and clean home
The hot tub was so nice and the rooms were very spacious and beds were comfortable
Some of which were fixed and others were not
Host:
They had 11 ladies and everyone slept very comfortably
Owner was friendly and easy to communicate with Made check-in hassle free
Ali was very responsive with any concerns
Love the hot tub and pool
The property comfortably slept all 12 of us
Location:
I rented this house for a group of ladies to get away
It's located about 10-15 minutes from the convention center
the location was perfect to out locations and walking to Old Town
The house is huge and very centrally located basically 15 minutes to every where It's also within walking distance to wonderful restaurants
It is also within walking distance to Old Town San Diego
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Beautiful Mission Hills

San Diego’s Mission Hills is indeed an affluent neighborhood in California that overlooks the picturesque Old Town San Diego. There are so many exquisite restaurants, entertainment centers, retail shops, and other well-visited establishments in this area. Surely, your time here will be worthwhile and memorable. If you are planning a vacation to Mission Hills any time soon, use this article of the best Vrbo accommodations in the area as your guide in choosing the best vacation home for you. May you have a fantastic vacation ahead.

Stayed at this property?
Any must-sees we missed? Tell us about them in the comments section or write a post here to help out fellow travelers!
Disclosure: Trip101 selects the listings in our articles independently. Some of the listings in this article contain affiliate links.

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