10 Best Airbnb Vacation Rentals In Hannibal, Missouri - Updated 2022


Situated along the grand banks of the Mississippi River, Hannibal brims with scenic, small-town charm. This quaint Missouri town was the birthplace of American author, Mark Twain (whose real name was actually Samuel Clemens), and Hannibal inspired the setting for Twain’s renowned novel - Tom Sawyer and Huckleberry Finn. There are several attractions that commemorate the author’s legacy and cultural impact, including the Mark Twain Boyhood Home and Museum, Mark Twain Cave Complex, and Mark Twain Riverboat cruise. For more great views, meander through Riverview Park for spectacular panoramas of the mighty Mississippi River, or step back into America’s Gilded Age and explore the grounds of Rockcliffe Mansion. The pleasant downtown is filled with lovely art galleries, unique monuments, and tons of terrific dining options. Enjoy history and small-town hospitality in this lovely Midwest town. Read the list below for the best Airbnb vacation rentals in Hannibal, Missouri.

1. Peaceful guest house with views of the Mississippi River (from USD 110)

Nestled on a scenic bluff, this lovely guest suite boasts wonderful views of the Mississippi River. The one-bedroom guest suite is airy and tranquil, and can accommodate up to four guests. Inside the property is a compact, well-equipped kitchen, a sunny living room that opens onto the dock, a dining area, a bedroom with a king-size bed, and a full bathroom. There is an additional queen-size bed located in the living room that can be separated from the rest of the room by a privacy curtain. Guests can also lounge on the private deck that overlooks the river and watch river boats cruise along.

Rocky Top Guesthouse on the River
Hannibal, Missouri, United States
271 reviews Superhost  Wifi Available
Entire bungalow 2 Beds 4 Guests 1 Bedroom 1 Bathroom

Accommodates: 4

Top guest reviews
Amenities & Room:
the deck had very comfortable furniture complete with zero gravity chairs
wonderful place with a view super clean and comfortable
the king bed was very comfortable
very welcoming clean comfortable and the view is awesome
amazing stay super clean privacy wonderful views awesome bed thoughtful touches
so clean and cozy
the house was spotless and extremely well appointed
great place to stay - clean
the house is very clean
it was absolutely spotless very easy to understand
host was always friendly and available
the host were great and very responsive
ted and carol are excellent hosts
ted and carol are excellent hosts
this is a fantastic place and the hosts are responsive and kind
the location is perfect as it is so close to the downtown sights
this is a lovely house in a great location
this is an amazing place to stay with close proximity to everything hannibal
great place to stay location is perfect 2 minutes from downtown and the cave/winery
the location is close to surrounding attractions and the down town area
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2. Private room in a historic building (from USD 122)

A cozy accommodation, this private room is comfortably furnished and features classic, Americana style. The room is located in a historic building, in the heart of downtown Hannibal, and includes elegant period details such as original hardwood floors and a 36-star flag appropriate to the time the building was constructed. The room includes a queen-size bed, and is equipped with Wi-Fi. Guests also have a private bathroom, and can utilize free on-site parking.

The Americana
Hannibal, Missouri, United States
17 reviews Superhost  Wifi Available
Private room in home 1 Bed 2 Guests 1 Bedroom 1 Bathroom

Accommodates: 2

Top guest reviews
Amenities & Room:
both were delightfully decorated very comfortable and enhanced our visit to mo
highly recommend this stay have experienced two of the rooms as currently offered
everything was fantastic wonderful location perfect amenities & such a cozy vibe
great place right in the center of riverfront hannibal
it is a great place and a great location
fantastic location in hannibal couldn’t be better it is right downtown and the americana room was so wonderfully decorated
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3. Unique house filled with Mark Twain artifacts (from USD 136)

A modern house with a distinctive style, this two-bedroom property is a wonderful accommodation for up to four guests. A unique homage to Hannibal’s most famous resident, this accommodation is filled with 1,200 items relating to Mark Twain, including personal photographs, fine art pieces, and a library filled with everything that Twain has written. The space includes a fully equipped kitchen, a large, comfortable living room that opens onto a deck, a dining area, two bedrooms, a full bathroom, and laundry machines. Guests can also relax on the private back deck, and free parking is available on the premises.

Night at the Twain Museum: Luxury Hannibal Retreat
Hannibal, Missouri, United States
129 reviews Superhost  Wifi Available
Entire home 2 Beds 4 Guests 2 Bedrooms 1 Bathroom

Accommodates: 4

Top guest reviews
Amenities & Room:
washer/dryer dishwasher a/c super close to downtown
huge tv with every channel
too much good stuff to say: beds were super huge and comfortable as was the sofa
the entire house was spotless and the beds and couch were super comfy
and the beds were extra comfortable
very clean and comfortable
paul’s place was clean and comfortable
great and very clean place with thoughtful details
great place to stay clean and homey
clean comfortable &easy to find
paul was a very nice host
paul was a great host
paul is a great host
paul was very helpful
paul is an excellent host
the location was wonderful and very close to historic downtown hannibal
super close to down town and quiet neighborhood
location to the downtown area was perfect
the location is perfect centrally located near lots of things to do in hannibal
charming little mark twain inspired place
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4. Well-equipped apartment near downtown Hannibal (from USD 100)

With its cozy interior and plethora of convenient amenities, this property is a great accommodation for a relaxing getaway in Hannibal. Situated within walking distance of the historic downtown, this apartment can accommodate up to five guests and features a rustic style. Inside, there is a sleek, well-equipped kitchen, a comfy living area with a sofa bed and additional single bed, a warm bedroom with a queen-size bed, and a modern bathroom. The property is close to the waterfront, and is just a short walk away from many of the town’s attractions.

77 reviews  Wifi Available
Entire rental unit 3 Beds 5 Guests 1 Bedroom 1 Bathroom

Accommodates: 5

Top guest reviews
the place was very clean and cool
lovely clean and comfortable place to stay
the space was clean larger than expected and cutely decorated
very good location within walking distance from everything down town
the location of this apartment is perfect
very cute space and so close to everything you need to be close to in hannibal
so many attractions are within walking distance
great place and great location
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5. Bright, two-bedroom house with modern amenities (from USD 110)

A spacious and airy property, this delightful house is a wonderful accommodation for up to four guests. The house is situated in a peaceful neighborhood, and is filled with modern amenities and comfortable furnishings. Inside the house is an open-planned living and dining space, a kitchen stocked with convenient essentials, two sunny bedrooms, a large bathroom, and laundry machines. Guests can also relax on the comfortable deck, as well as the scenic back patio, which is equipped with a barbecue grill and outdoor furniture.

Modern 2 Bdr House in Great Neighborhood.
Hannibal, Missouri, United States
168 reviews Superhost  Wifi Available
Entire home 2 Beds 4 Guests 2 Bedrooms 1 Bathroom

Accommodates: 4

Top guest reviews
Amenities & Room:
felt very relaxed and comfortable there with all the amenities
you will love this lil house and patio and will be very comfortable here
the bed had a nice firm and comfortable mattress - a plus nice quiet neighborhood
very clean comes as advertised
super clean and stylish
very clean with comfortable beds
very clean modern and uncluttered
it was very clean and in a quiet neighborhood
jason was kind and attentive
jason is a wonderful host that responds quickly
good host and good space
the hosts were very quick to respond and the accommodations were very nice
nice place and great host
great house in a great location
this was the perfect location for my family to get away to hannibal for the first time
was in a great location and nice neighborhood
close to downtown yet on a quiet street in a lovely neighborhood
location was convenient to the river mark twain cave and other attractions
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6. Well-equipped apartment best for couples and solo travelers

A pleasant accommodation for solo travelers or couples, this casual apartment is cozy and well-equipped. The apartment includes a well-stocked kitchen, a comfy living room, a bedroom with a queen-size bed, and a spacious bathroom. Free on-street parking is available, and the apartment also has Wi-Fi and air conditioning. The historic downtown is within walking distance, and many restaurants, shops, and museums are nearby.

Downtown Apartment
Hannibal, Missouri, United States
173 reviews
Entire apartment 1 Bed 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
the couch and bed are super comfy
oh and the space heaters were great
it had a lot of great amenities including a private kitchen living space and bathroom
comfy bed and couch and was nicely decorated as well
very comfortable apartment with everything necessary for a short stay
nice towels and clean bathroom
very clean and comfortable
clean private and easy to communicate with
the space was clean and perfect for our short stay
clean and felt like home
jim was a good host
he was around to answer questions and give helpful advice
jim is a great host
jim is a good host
jim is a great host--very helpful
location is perfect
great location—walking distance to everything downtown
super short walking distance
great location and very comfortable
great location in the historical hometown of mark twain
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7. Simple apartment near downtown Hannibal

Located in a convenient location, this apartment is a great vacation rental for couples or solo travelers. The property is within walking distance of downtown Hannibal, and many museums, restaurants, and shops are close by. Inside the apartment is a cozy living area, a modern, fully equipped kitchen, a sleek bathroom, and a large bedroom. The apartment is air conditioned, and comes with a Wi-Fi connection, should you wish to get some work done. Free parking is also available on the premises.

Downtown Apartment 2
Hannibal, Missouri, United States
68 reviews
Entire apartment 1 Bed 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
nice introduction letter with area tips wifi and tv with access to hulu netflix etc
beautiful apartment and very clean
very clean in the heart of hannibal
great place clean with great touches
the living space is very clean and comfortable
all good clean comfortable bed and convenient
jim was a great host
jim is a wonderful host
jim was an excellent host
great owner so nice
jim communicated well and was a great host
very close to attractions
the location is walking distance to all the main attractions
great location with easy walking distance to many local attractions
convenient location and perfect space
very comfortable space in a convenient location
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8. Quaint apartment in a quiet area

Peaceful and pleasant, this cozy house is a delightful accommodation for families or small groups. The two-bedroom home can accommodate up to five guests, and is filled with comfortable furnishings. The space is private and tranquil, and includes a roomy living area, a kitchen filled with convenient utensils and appliances, a full bathroom, a large bedroom with both a queen-size and a single bed, and a smaller bedroom with a twin-size bed. There is also a screened-in porch, Wi-Fi and air conditioning. Plenty of street parking is also available.

Relaxation Ranch
Hannibal, Missouri, United States
64 reviews
Entire apartment 4 Beds 2 Bedrooms 2 Bathrooms
Top guest reviews
Amenities & Room:
only suggestion is to improve the wifi signal as everyone in our party had difficulty staying connected
two beds and two baths were a great setup for traveling with a toddler
i especially loved her peacock table coffee is there and everything is in place to use the kitchen
we loved the huge master bedroom along with the nice kitchen and living room
everything was very clean and comfortable
very clean place in a quiet neighborhood
it is clean private and comfortable
her place was clean and comfortable
it is very clean nicely kept and had just what we needed
terrie was a great host
terri is a great host
terri was a wonderful host she made sure we had everything that we needed
owners of one gave us good suggestions for riding
it was exactly as described she was friendly and made it a pleasant stay while giving you your space
location is quiet and peaceful
it's location provides easy access to downtown hannibal
very nice place with a great location
location is perfect and easy to find
the neighborhood is quiet with easy access by car to downtown
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9. Charming loft in downtown Hannibal

This airy loft apartment provides a peaceful and comfortable guest experience in downtown Hannibal. Filled with cozy furnishings, this one-bedroom apartment is spacious and well-equipped, and can accommodate up to two guests. Within the apartment is a fully equipped kitchen filled with sleek appliances, a large living room, a full bathroom, and an airy bedroom with a king-size bed. The apartment is situated close to the town’s main street, and is near many restaurants, shops, and attractions within the town.

Hidden River Loft
Hannibal, Missouri, United States
33 reviews
Entire loft 1 Bed 1 Bedroom 1 Bathroom
Top guest reviews
Amenities & Room:
the space is generous and comfortable
the loft was clean and had everything we required
this space was amazing: huge clean private and stylishly equipped
sparkling clean we loved the location and welcome guide
the host was so helpful and responsive
the host responds quickly and is very helpful
loretta was friendly and welcoming
lori was very helpful and responsive
very cute and comfortable place right off main strip
easy walk to everything
great location if you are enjoying downtown hannibal
location to downtown is wonderful
perfect location to enjoy historic hannibal
Read more reviews

10. Historic Victorian mansion with water views

A historic style and modern amenities make this charming house a luxurious place to stay in Hannibal. The property showcases Gilded Age historic features and can provide accommodation for up to 10 guests. Inside the house is a chic, contemporary kitchen, an airy living room, a cozy dining room, four elegant bedrooms, and two large bathrooms. There is also a spacious deck, where guests can relax in the evening. The property is within walking distance of downtown Hannibal, and is close to the Mark Twain Boyhood Home and Museum.

Historic Victorian Mansion with a Modern Flair
Hannibal, Missouri, United States
93 reviews  Wifi Available
Entire residential home 5 Beds 12 Guests 4 Bedrooms 2 Bathrooms

Accommodates: 12

Top guest reviews
Amenities & Room:
the kitchen and front/side porch are a fantastic place for morning coffee or evening cocktails
wonderful home beautifully appointed with a terrific kitchen and granite-topped kitchen island perfect for visiting and snacking with friends/family
kitchen was very well stocked even with salt and pepper and coffee and filters
large bedrooms and beautiful bathrooms made it perfect for our get-away
towels and bed linen were clean
very clean & beautiful
beautiful and extremely clean historic home
beautiful house was super clean
house was clean and comfortable and there were many extra towels and blankets to go around
the hosts were nice and easy to talk to
great host and we definitely will want to stay again in the future
nicole and bruno were wonderful in responding and very friendly and accommodating to work with
gorgeous historic home near everything host was so easy to work with
great location to main street walking distance to rock cliff mansion
short walk to town attractions
great location to restaurants on main st
absolutely beautiful home in a great location
everything is an easy walk and the neighborhood is full of old houses of considerable interest
Read more reviews

Have a wonderful time in Hannibal

With its quaint downtown and engaging cultural attractions, Hannibal is a wonderful destination in the Midwest. This delightful town brims with history and hospitality, and is a fantastic place to soak up the peaceful ambiance of the river. Check out these Airbnb vacation rentals for a comfortable stay in Hannibal, Missouri.

Disclosure: Trip101 selects the listings in our articles independently. Some of the listings in this article contain affiliate links.

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Hannah is a freelance writer, list making aficionado, and world traveler currently based in Germany. She is an avid explorer, and believes in creating new experiences to put on her bucket list to...Read more

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