Missouri — or The Show Me State — is known for its agricultural richness and barbecues. Besides that, this charming state features many great cities that are worth a visit, such as Cape Girardeau. This incredible city, lying along the Mississippi River, has so much to offer. For a fun-filled holiday with your family, visit Cape Splash Family Aquatic Center or Cape Safari Park. If you are here for a historic adventure, Crisp Museum, The Glenn House, and Fort D Historic Site are great places to stop by. Cape Girardeau also features many antique shops and wineries if you want to make the most of your time here.
This city is truly a must-visit destination. So, if you want to see what it is all about, make sure to find great accommodation. Read on for the best hotels in Cape Girardeau, Missouri.
We handpicked these listings carefully, considering (wherever possible) Superhost status, recent guest reviews, location, accommodation type, prices, availability of dates, decor, and amenities. The image galleries get refreshed with the latest updates regularly. They were last updated on October 30, 2025.
1. Drury Plaza Hotel Cape Girardeau Conference Center (from USD 111)
Comfort and entertainment await at Drury Plaza Hotel Cape Girardeau Conference Center. This 3-star property offers easy access to many attractions, such as the famous Show Me Center and Century Casino Cape Girardeau. But before heading out, energize by indulging in the free breakfast buffet in the hotel. To keep updated on the latest happenings, use the free Wi-Fi. Moreover, the 24-hour front desk is always ready to help you out.
To cool off, head to the indoor pool and have a relaxing swim.
Drury Plaza Hotel Cape Girardeau Conference Center
Address: 3351 Percy Drive
3.83 km (2.4 mi) from Capaha Park
2. Candlewood Suites Cape Girardeau, an IHG Hotel (from USD 88)
Candlewood Suites Cape Girardeau, an IHG Hotel is the place to be if you want to be close to conveniences, such as restaurants and Saint Francis Medical Center. This property has been newly renovated, providing better amenities and facilities for a more enjoyable stay. Those who are here for business can take advantage of the complimentary, speedy Wi-Fi. There is also a 24-hour business center here.
Candlewood Suites Cape Girardeau by IHG
Address: 485 S Mount Auburn Rd
4.03 km (2.5 mi) from Capaha Park
3. Courtyard by Marriott Cape Girardeau Downtown (from USD 168)
Have a splendid time at Courtyard by Marriott Cape Girardeau Downtown. As soon as you enter the premises, your eyes will feast on the updated lobby — a great spot to just relax and hang out. The hotel provides a fitness center, so you can keep up with your workout. Wi-Fi is also free to use.
For breakfast and dinner, head to The Bistro. This on-site restaurant boasts scrumptious American fare to liven you up.
Courtyard by Marriott Cape Girardeau Downtown
Address: 400 Broadway St.
1.49 km (1.0 mi) from Capaha Park
4. Hampton Inn Cape Girardeau I 55 East (from USD 123)
Book a room in this hotel and be guaranteed a hassle-free stay experience. All rooms here include a refrigerator and microwave, so you can store perishables and heat up takeaways with ease. Up to two pets can stay with you in the room as long as you pay the necessary fee and that they weigh a maximum of 75 lb (34.02 kg).
This hotel is also situated about a 10-minute walk away from West Park Mall.
Hampton Inn Cape Girardeau I 55 East
Address: 207 S Mt Auburn Rd
3.64 km (2.3 mi) from Capaha Park
5. Drury Inn & Suites Cape Girardeau (from USD 116)
Located in the city center, this lovely hotel is the perfect base for your adventures in Cape Girardeau. The relaxation of guests is one of the priorities here. They can go for a swim in the indoor pool or hot tub, enjoy coffee or tea in the lobby, or simply stay in their stunning room. If you are bringing your little one with you, the hotel also offers free cribs.
Drury Inn & Suites Cape Girardeau
Address: 3303 Campster Drive
4.12 km (2.6 mi) from Capaha Park
6. Quality Inn (from USD 79)
Choose Quality Inn if you want affordable yet comfortable accommodation. This charming hotel is close to many restaurants and historic attractions, so you can easily explore parts of Cape Girardeau. There is a seasonal outdoor pool on the premises, ideal for relaxation.
In the mornings, the hotel offers a hot breakfast. However, if you are craving a midnight snack, there are also vending machines available.
Quality Inn
Address: 2011 North Kingshighway
4.65 km (2.9 mi) from Capaha Park
7. Holiday Inn Express Hotel & Suites Cape Girardeau I-55, an IHG Hotel (from USD 114)
All the 102 suites in this property are air-conditioned and feature amenities ranging from laptop-friendly workspaces to free toiletries. Here on a business trip? The hotel provides two meeting rooms with appropriate equipment. To get started on your day, enjoy a free breakfast. Some food options include their signature cinnamon rolls and eggs.
If you are going here by car, the hotel also provides free self-parking.
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Address: 3253 William Street
3.71 km (2.4 mi) from Capaha Park
8. Pear Tree Inn Cape Girardeau West (from USD 81)
This hotel is situated just 3.6 mi (5.79 km) away from Southeast Missouri State University and 4.6 mi (7.40 km) from the gorgeous Cape Girardeau Conservation Nature Center. But besides its prime location, this hotel itself is also a wonder to behold. The 81 rooms here feature pleasing pops of color, adding character to the space. For your caffeine fix, there are also coffee and tea makers in the room. Wi-Fi is available for free, too.
Pear Tree Inn Cape Girardeau West
Address: 103 Cape West Pkwy
4.03 km (2.5 mi) from Capaha Park
9. Auburn Place Hotel And Suites
Auburn Place Hotel And Suites offers lovely rooms with dark wooden furniture and neutral tones, exuding a welcoming and low-key atmosphere throughout. In the morning, you can indulge in a hearty breakfast for free to start your day on the right note.
Those who like to keep active can head to the indoor pool or the fitness center. Services, such as daily housekeeping and laundry, are also available.
Auburn Place Hotel And Suites
Address: 3265 William St
3.77 km (2.4 mi) from Capaha Park
Connect with Cape Girardeau
Cape Girardeau boasts a perfect harmony of historic and modern offerings, giving you the opportunity to experience the best of both worlds. Review the above list of the best hotels in the city and choose one that you think is best for you.
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